Polygodial

Tocris Bioscience, part of Bio-Techne | Catalog # 3197

TRPA1 channel activator; analgesic and antifungal
Discontinued Product
3197 has been discontinued. View all TRPA1 Activators products.

Key Product Details

Description

TRPA1 channel activator; analgesic and antifungal

View all TRPA1 Activators »

Product Description

Polygodial is a TRPA1 channel activator (EC50 = 400 nM) that is selective against TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 channels. Acts as an analgesic via desensitization of sensory neurons. Also exhibits antifungal activity via inhibition of mitochondrial ATPase.

Product Specifications

Molecular Weight

234.33

Formula

C15H22O2

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde

CAS Number

6754-20-7

PubChem ID

72503

InChI Key

AZJUJOFIHHNCSV-KCQAQPDRSA-N

SMILES

[H][C@]12C(C)(C)CCC[C@@](C)1[C@@H](C=O)C(C=O)=CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.43 100
Ethanol 23.43 100

Preparing Stock Solutions for Polygodial

The following data is based on the product molecular weight 234.33

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.27 mL 21.34 mL 42.67 mL
5 mM 0.85 mL 4.27 mL 8.53 mL
10 mM 0.43 mL 2.13 mL 4.27 mL
50 mM 0.09 mL 0.43 mL 0.85 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Polygodial

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Polygodial

For research use only

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