Polygodial

Name: Polygodial
Brand: Tocris Bioscience
SKU: 3197

Tocris Bioscience a Bio-Techne Brand

Catalog # 3197

Citations (2)

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Key Product Details

Description:	TRPA1 channel activator; analgesic and antifungal
Chemical Name:	(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde
Purity:	≥97% (HPLC)
Molecular Weight:	234.33

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Biological Activity for Polygodial

Polygodial is a TRPA1 channel activator (EC₅₀ = 400 nM) that is selective against TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 channels. Acts as an analgesic via desensitization of sensory neurons. Also exhibits antifungal activity via inhibition of mitochondrial ATPase.

Compound Libraries for Polygodial

Polygodial is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Polygodial

M. Wt	234.33
Formula	C₁₅H₂₂O₂
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	6754-20-7
PubChem ID	72503
InChi Key	AZJUJOFIHHNCSV-KCQAQPDRSA-N
Smiles	[H][C@]12C(C)(C)CCC[C@@](C)1[C@@H](C=O)C(C=O)=CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Polygodial

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	23.43	100
	ethanol	23.43	100

Preparing Stock Solutions for Polygodial

The following data is based on the product molecular weight 234.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.27 mL	21.34 mL	42.67 mL
5 mM	0.85 mL	4.27 mL	8.53 mL
10 mM	0.43 mL	2.13 mL	4.27 mL
50 mM	0.09 mL	0.43 mL	0.85 mL

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References for Polygodial

References are publications that support the biological activity of the product.

Escalera TRPA1 mediates the noxious effects of natural sesquiterpene deterrents. J.Biol.Chem. 2008 PMID: 18550530
Matsuda Protective effect of polygodial and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action. Bioorg.Med.Chem.Letts. 2002 PMID: 11814823
Lunde and Kubo Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae. Antimicrob.Agents Chemother. 2000 PMID: 10858359

Citations for Polygodial (2)

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Citations are publications that use Bio-Techne products. Selected citations for Polygodial include:

Silverman et al. (2023) Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1� induced hypothermia and reflex anti-inflammatory responses. Mol Med. 29:4
PMID: 36650454
Shi et al. (2015) Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. Mol Cancer. 21:4852
PMID: 25944998

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