(+)-UH 232 maleate

Name: (+)-UH 232 maleate
Brand: tocris
SKU: 0775

Catalog # 0775

Datasheet / COA / SDS

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Key Product Details

Description:	D₂ autoreceptor antagonist. Also D₃ partial agonist
Chemical Name:	cis-(+)-5-Methoxy-1-methyl-2-(di-N-propylamino)tetralin maleate

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Biological Activity

D₂ antagonist (K_i = 72.7 nM in a ligand binding assay; apparent K_B = 14.5 nM in a cAMP accumulation assay); displays preferential activity at central dopamine autoreceptors. Stimulates a marked acceleration of dopamine synthesis and turnover. Produces locomotor stimulation. Exhibits little or no activity at central noradrenalin and 5-HT receptors. Also D₃ partial agonist.

Technical Data

M. Wt	391.51
Formula	C₁₈H₂₉NO.C₄H₄O₄
Storage	Store at RT
CAS Number	1217473-50-1
PubChem ID	46830250
InChi Key	MEQAJDYHKYAPJE-GUUGRXDUSA-N
Smiles	OC(=O)\C=C/C(O)=O.CCCN(CCC)[C@@H]1CCC2=C(C=CC=C2OC)[C@@H]1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		50

Preparing Stock Solutions

The following data is based on the product molecular weight 391.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.11 mL	25.54 mL	51.08 mL
2.5 mM	1.02 mL	5.11 mL	10.22 mL
5 mM	0.51 mL	2.55 mL	5.11 mL
25 mM	0.10 mL	0.51 mL	1.02 mL

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References

References are publications that support the biological activity of the product.

Griffon The preferential DA D₃ receptor ligand, (+)-UH 232, is a partial agonist. Eur.J.Pharmacol. 1995 PMID: 7498261
Hall and Strange Evidence that antipsychotic drugs are inverse agonists at D₂ DA receptors. Br. J. Pharmacol. 1997 PMID: 9208141
Johansson Novel DA receptor agonists and antagonists with preferential action on autoreceptors. J.Med.Chem. 1985 PMID: 3927002
Svensson (+)-AJ 76 and (+)-UH 232: central stimulants acting as preferential DA autoreceptor antagonists. Naunyn Schmiedebergs Arch.Pharmacol. 1986 PMID: 2880302

Citations

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Product Datasheets

COA

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service.