PHM 27 (human)

Name: PHM 27 (human)
Brand: Tocris Bioscience
SKU: 2080

Catalog # 2080 | Tocris Bioscience a Bio-Techne Brand

COA / SDS

Potent calcitonin agonist; endogenous analog of human VIP

Discontinued Product

2080 has been discontinued. View all Calcitonin and Related Receptor Agonists products.

Key Product Details

Description:	Potent calcitonin agonist; endogenous analog of human VIP
Alternative Names:	Peptide histidine methionine 27 (human), Human PHI 27
Molecular Weight:	2985.44

View Full Technical Details for PHM 27 (human)

Technical Data
Citations / Reviews

Biological Activity for PHM 27 (human)

PHM 27 (human) is an endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC₅₀ = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β-islets display enhanced glucose-induced insulin secretion.

Technical Data for PHM 27 (human)

M. Wt	2985.44
Formula	C₁₃₅H₂₁₄N₃₄O₄₀S
Single Letter Sequence	HADGVFTSDFSKLLGQLSAKKYLESLM (Modifications: Met-27 = C-terminal amide)
Storage	Desiccate at -20°C
CAS Number	87403-73-4
PubChem ID	16133840
InChi Key	YLBIOQUUAYXLJJ-WZUUGAJWSA-N
Smiles	[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PHM 27 (human)

References are publications that support the biological activity of the product.

Ma Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor. Biochem.Pharmacol. 2004 PMID: 15013843
Kato Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic β cells. J.Biol.Chem. 1994 PMID: 8063743
Itoh Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature 1983 PMID: 6571696

Citations for PHM 27 (human)

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