PhiKan 083

Name: PhiKan 083
Brand: Tocris Bioscience
SKU: 4326

Tocris Bioscience, part of Bio-Techne | Catalog # 4326

Citations (6)

COA / SDS

p53 stabilizing agent

Discontinued Product

4326 has been discontinued. View all Additional p53-related Compounds products.

Key Product Details

Description:	p53 stabilizing agent
Chemical Name:	9-Ethyl-N-methyl-9H-carbazole-3-methanamine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	274.79

View Full Technical Details for PhiKan 083

Technical Data
Citations

Biological Activity for PhiKan 083

PhiKan 083 is a p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Slows rate of thermal denaturation of p53-Y220C.

Compound Libraries for PhiKan 083

PhiKan 083 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PhiKan 083

M. Wt	274.79
Formula	C₁₆H₁₈N₂.HCl
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1050480-30-2
PubChem ID	16255105
InChi Key	IXWVUPURFWFRNE-UHFFFAOYSA-N
Smiles	CCN1C3=C(C=CC=C3)C2=C1C=CC(CNC)=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PhiKan 083

References are publications that support the biological activity of the product.

Wiman Pharmacological reactivation of mutant p53: from protein structure to the cancer patient. Oncogene. 2010 PMID: 20498645
Boeckler Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc.Natl.Acad.Sci. 2008 PMID: 18650397