[Phe⁸Ψ(CH-NH)-Arg⁹]-Bradykinin

Name: [Phe 8 Ψ(CH-NH)-Arg 9 ]-Bradykinin
Brand: Tocris Bioscience
SKU: 3229
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3229

(1)

Citations (1)

COA / SDS

Selective B2 agonist

Discontinued Product

3229 has been discontinued. View all Bradykinin Receptor Agonists products.

Key Product Details

Description:	Selective B₂ agonist
Purity:	≥95% (HPLC)
Molecular Weight:	1046.23

View Full Technical Details for [Phe⁸Ψ(CH-NH)-Arg⁹]-Bradykinin

Technical Data
Citations / Reviews (1)

Biological Activity

[Phe⁸Ψ(CH-NH)-Arg⁹]-Bradykinin is a selective bradykinin B₂ receptor agonist that is resistant to carboxypeptidase cleavage. 5-fold more potent and exhibits a more prolonged duration of action than bradykinin (Cat No. 3004) in vivo.

Technical Data

M. Wt	1046.23
Formula	C₅₀H₇₅N₁₅O₁₀
Single Letter Sequence	RPPGFSPFR (Modifications: Phe-8 - Arg-9 peptide bond replaced with Ψ-(CH₂-NH))
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	118122-39-7
PubChem ID	3082903
InChi Key	XKJBISGEHGXKBF-TZPCGENMSA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@H](CN[C@@H](CCCNC(N)=N)C(O)=O)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References

References are publications that support the biological activity of the product.

Marceau Kinin receptors: functional aspects. Int.Immunopharmacol. 2002 PMID: 12489786
Leeb-Lundberg International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 2005 PMID: 15734727
Drapeau [Phe⁸Ψ(CH₂-NH)Arg⁹]bradykinin, a B₂ receptor selective agonist which is not broken down by either kininase I or kininase II. Eur.J.Pharmacol. 1988 PMID: 2907489

[Phe⁸Ψ(CH-NH)-Arg⁹]-Bradykinin

Tocris Bioscience, part of Bio-Techne | Catalog # 3229

Key Product Details

Biological Activity

Technical Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

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[Phe8Ψ(CH-NH)-Arg9]-Bradykinin

Tocris Bioscience, part of Bio-Techne | Catalog # 3229

Key Product Details

Biological Activity

Technical Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

[Phe⁸Ψ(CH-NH)-Arg⁹]-Bradykinin