PFI 4

Name: PFI 4
Brand: Tocris Bioscience
SKU: 5576

Tocris Bioscience, part of Bio-Techne | Catalog # 5576

COA / SDS

Potent and selective BRPF1B bromodomain inhibitor

Discontinued Product

5576 has been discontinued. View all Bromodomain Inhibitors products.

Key Product Details

Description:	Potent and selective BRPF1B bromodomain inhibitor
Chemical Name:	N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide
Purity:	≥99% (HPLC)
Molecular Weight:	380.44

View Full Technical Details for PFI 4

Technical Data
Citations

Biological Activity for PFI 4

PFI 4 is a potent and selective BRPF1B bromodomain inhibitor (IC₅₀ = 172 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. Disrupts BRPF1 binding to histone H3.3. Cell permeable. Inhibits osteoclastogenesis.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the PFI 4 probe summary on the SGC website.

Compound Libraries for PFI 4

PFI 4 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for PFI 4

M. Wt	380.44
Formula	C₂₁H₂₄N₄O₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	900305-37-5
PubChem ID	40642506
InChi Key	QCIJLRJBZDBVDB-UHFFFAOYSA-N
Smiles	CN(C1=CC(NC(C2=C(OC)C=CC=C2)=O)=C(N3CCCC3)C=C1N4C)C4=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PFI 4

References are publications that support the biological activity of the product.

Meier Selective targeting of bromodomains of the bromodomain-PHD fingers family impairs osteoclast differentiation. ACS Chem.Biol. 2017 PMID: 28849908
Demont 1,3-Dimethyl Benzimidazolones are potent, selective inhibitors of the BRPF1 bromodomain. ACS Med.Chem.Lett. 2014 PMID: 25408830