PF CBP1
Tocris Bioscience, part of Bio-Techne | Catalog # 5801
Selective CBP/p300 bromodomain inhibitor
Discontinued Product
5801 has been discontinued.
View all Bromodomain Inhibitors products.
Key Product Details
Description
Selective CBP/p300 bromodomain inhibitor
Product Description
Selective CBP/p300 bromodomain inhibitor (IC50 values are 125 and 363 nM, respectively). Exhibits >100-fold selectivity for CBP over BRD4. Also exhibits selectivity over a panel of other bromodomains. Reduces LPS-induced IL-1β, IL-6 and IFN-β expression in macrophages in vitro. Also downregulates RGS4 expression in primary cortical neurons in vitro.Negative Control also available.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.External Portal Informaiton
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF CBP1 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
488.62
Formula
C29H36N4O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
5-(Dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]-1H-1,3-benzodiazole
CAS Number
1962928-21-7
PubChem ID
119081417
InChI Key
CGWBJJZOKGZCSJ-UHFFFAOYSA-N
SMILES
CC(ON=C1C)=C1C2=CC(N=C(CCC3=CC=C(OCCC)C=C3)N4CCN5CCOCC5)=C4C=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.86 | 100 | |
| Ethanol | 48.86 | 100 |
Preparing Stock Solutions
for PF CBP1
The following data is based on the product molecular weight 488.62
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.05 mL | 10.23 mL | 20.47 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.09 mL |
| 10 mM | 0.20 mL | 1.02 mL | 2.05 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chekler Transcriptional profiling of a selective CREB binding protein bromodomain inhibitor highlights therapeutic opportunities. Chem.Biol. 2015 PMID: 26670081
Product Specific Notices for PF CBP1
For research use only
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