PF 8380

Name: PF 8380
Brand: Tocris Bioscience
SKU: 4078
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4078

(2)

COA / SDS

Potent autotaxin inhibitor

Discontinued Product

4078 has been discontinued. View all Autotaxin Inhibitors products.

Key Product Details

Description:	Potent autotaxin inhibitor
Chemical Name:	3,5-Dichlorobenzyl-[4-[3-oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]]piperazine-1-carboxylate
Purity:	≥97% (HPLC)
Molecular Weight:	478.33

View Full Technical Details for PF 8380

Technical Data
Citations / Reviews (2)

Biological Activity for PF 8380

PF 8380 is a potent autotaxin inhibitor (IC₅₀ = 2.8 nM in isolated enzyme assay; 101 nM in human whole blood). Modulates lysophosphatidic acid (LPA) levels in vivo and in vitro by directly inhibiting autotaxin; reduces LPA levels both in plasma and at site of inflammation. Decreases leptin-induced MMP13 expression, in vitro. Orally available.

Technical Data for PF 8380

M. Wt	478.33
Formula	C₂₂H₂₁Cl₂N₃O₅
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	1144035-53-9
PubChem ID	25265312
InChi Key	JMSUDQYHPSNBSN-UHFFFAOYSA-N
Smiles	O=C(C2=CC(OC(N4)=O)=C4C=C2)CCN1CCN(C(OCC3=CC(Cl)=CC(Cl)=C3)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PF 8380

References are publications that support the biological activity of the product.

Jankowski Autotaxin: its role in biology of melanoma cells and as a pharmacological target. Enzyme Res. 2011 PMID: 21423677
Poulami High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature. Sci.Rep. 2017 PMID: 28811491
Gierse A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation. J.Pharmacol.Exp.Ther. 2010 PMID: 20392816

PF 8380

Tocris Bioscience, part of Bio-Techne | Catalog # 4078

Key Product Details

Biological Activity for PF 8380

Technical Data for PF 8380

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for PF 8380

Product Documents for PF 8380

COA

Certificate of Analysis

SDS

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