PD 90780

Name: PD 90780
Brand: Tocris Bioscience
SKU: 5101

Tocris Bioscience, part of Bio-Techne | Catalog # 5101

Citations (1)

COA / SDS

Inhibits NGF binding to p75NTR

Discontinued Product

5101 has been discontinued. View all Trk Receptor Inhibitors products.

Key Product Details

Description:	Inhibits NGF binding to p75^NTR
Chemical Name:	7-(Benzoylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	362.34

View Full Technical Details for PD 90780

Technical Data
Citations

Biological Activity for PD 90780

PD 90780 is a a nonpeptide inhibitor of NGF binding to p75^NTR (IC₅₀ ~ 1 μM in CHO cells); binds NGF, not p75^NTR. Affinity maybe altered by the presence of TrkA receptors. Neuroprotective.

Technical Data for PD 90780

M. Wt	362.34
Formula	C₁₉H₁₄N₄O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	77422-99-2
PubChem ID	9885305
InChi Key	IAZAGXDMMVWYKF-UHFFFAOYSA-N
Smiles	O=C(C4=CC=CC=C4)NC1=CC=C3C(C(N2C(N3C)=CC(C(O)=O)=N2)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PD 90780

References are publications that support the biological activity of the product.

Eibl Structural, biological, and pharmacological strategies for the inhibition of nerve growth factor. Neurochem.Int. 2012 PMID: 23103525
Longo Small molecule modulation of p75 neurotrophin receptor functions. CNS Neurol.Disord.Drug Targets 2008 PMID: 18289033
Colquhoun Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J.Pharmacol.Exp.Ther. 2004 PMID: 15051797

PD 90780

Tocris Bioscience, part of Bio-Techne | Catalog # 5101

Key Product Details

Biological Activity for PD 90780

Technical Data for PD 90780

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for PD 90780

Product Documents for PD 90780

COA

Certificate of Analysis

SDS

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