PD 153035 hydrochloride

Name: PD 153035 hydrochloride
Brand: Tocris Bioscience
SKU: 1037

Tocris Bioscience, part of Bio-Techne | Catalog # 1037

Citations (27)

COA / SDS

EGFR-kinase inhibitor

Discontinued Product

1037 has been discontinued. View all EGF Receptor Inhibitors products.

Key Product Details

Description:	EGFR-kinase inhibitor
Alternative Names:	ZM 252868
Chemical Name:	4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride
Molecular Weight:	396.67

View Full Technical Details for PD 153035 hydrochloride

Technical Data
Citations

Biological Activity for PD 153035 hydrochloride

An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC₅₀ of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data for PD 153035 hydrochloride

M. Wt	396.67
Formula	C₁₆H₁₄BrN₃O₂.HCl
Storage	Store at RT
CAS Number	183322-45-4
PubChem ID	11246488
InChi Key	ZJOKWAWPAPMNIM-UHFFFAOYSA-N
Smiles	BrC1=CC=CC(NC3=NC=NC2=CC(OC)=C(OC)C=C23)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PD 153035 hydrochloride

References are publications that support the biological activity of the product.

Bridges Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J.Med.Chem. 1996 PMID: 8568816
Fry A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science 1994 PMID: 8066447
Bos PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin.Cancer Res. 1997 PMID: 9815602