PD 153035 hydrochloride

Name: PD 153035 hydrochloride
Brand: tocris
SKU: 1037

Catalog # 1037

Citations (5)

Datasheet / COA / SDS

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$35 to United States

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Key Product Details

Description:	EGFR-kinase inhibitor
Alternative Names:	ZM 252868
Chemical Name:	4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride
Molecular Weight:	396.67

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Biological Activity

An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC₅₀ of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt	396.67
Formula	C₁₆H₁₄BrN₃O₂.HCl
Storage	Store at RT
CAS Number	183322-45-4
PubChem ID	11246488
InChi Key	ZJOKWAWPAPMNIM-UHFFFAOYSA-N
Smiles	BrC1=CC=CC(NC3=NC=NC2=CC(OC)=C(OC)C=C23)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.97	10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 396.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.21 mL	126.05 mL	252.10 mL
0.5 mM	5.04 mL	25.21 mL	50.42 mL
1 mM	2.52 mL	12.60 mL	25.21 mL
5 mM	0.50 mL	2.52 mL	5.04 mL

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References

References are publications that support the biological activity of the product.

Bos PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin.Cancer Res. 1997 PMID: 9815602
Bridges Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J.Med.Chem. 1996 PMID: 8568816
Fry A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science 1994 PMID: 8066447

Citations (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for PD 153035 hydrochloride include:

Marshall et al. (2018) Analysis of the Intrinsic Self-Organising Properties of Mesenchymal Stromal Cells in Three-Dimensional Co-Culture Models with Endothelial Cells. Bioengineering (Basel). 5
PMID: 30373192
Lahey et al. (2017) Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function. PLoS One. 12:e0180259
PMID: 28671992
Taylor et al. (2014) Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition. Breast Cancer Res Treat. 144:551
PMID: 24610032
Swanson et al. (2012) Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis. J Immunol. 188:3513
PMID: 22393153
Xu (2007) EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas. Cancer Res. 67:6121
PMID: 17616668

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Showing 1 - 5 of 5 citations Showing All

Product Datasheets

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Certificate of Analysis

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PD 153035 hydrochloride

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Biological Activity

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References

Citations (5)

Product Datasheets

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