Pancuronium dibromide

Name: Pancuronium dibromide
Brand: tocris
SKU: 0693

Catalog # 0693

Citations (2)

Datasheet / COA / SDS

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Key Product Details

Description:	Neuromusclar nAChR antagonist
Chemical Name:	1,1'-(3α,17β-Dihydroxy-2β,5α-androstan-2β,16β-ylene) bis[1-methylpiperidinium] diacetate dibromide
Purity:	≥99%
Molecular Weight:	732.68

View Full Technical Details for Pancuronium dibromide

Biological Activity

Nicotine (neuromuscular) antagonist. Skeletal muscle relaxant.

Technical Data

M. Wt	732.68
Formula	C₃₅H₆₀Br₂N₂O₄
Storage	Desiccate at RT
Purity	≥99%
CAS Number	15500-66-0
PubChem ID	23581810
InChi Key	NPIJXCQZLFKBMV-TZJMVAHLSA-L
Smiles	[H][C@]34C2([H])CC[C@@]1([H])C[C@H](OC(C)=O)C([N+]6(C)CCCCC6)CC(C)1[C@]([H])2CCC(C)3C(OC(C)=O)C([N+]5(C)CCCCC5)C4.[Br-].[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	73.27	100

Preparing Stock Solutions

The following data is based on the product molecular weight 732.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.36 mL	6.82 mL	13.65 mL
5 mM	0.27 mL	1.36 mL	2.73 mL
10 mM	0.14 mL	0.68 mL	1.36 mL
50 mM	0.03 mL	0.14 mL	0.27 mL

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References

References are publications that support the biological activity of the product.

Fryer and Maclagan Pancuronium and gallamine are antagonists for pre- and post-junctional muscarinic receptors in the guinea-pig lung. Naunyn Schmiedebergs Arch.Pharmacol. 1987 PMID: 3600815
Lowenick Open channel and competitive block of nicotinic receptors by pancur. and atrac. Eur.J.Pharmacol. 2001 PMID: 11173060
Maestrone Extracellular pancur. affects sodium current in chick embryo sensory neurones. Br.J.Pharmacol. 1994 PMID: 8012707
Merck Index

Citations (2)

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Citations are publications that use Bio-Techne products. Selected citations for Pancuronium dibromide include:

Candelier et al. (2015) A microfluidic device to study neuronal and motor responses to acute chemical stimuli in zebrafish. Invest Ophthalmol Vis Sci. 5:12196
PMID: 26194888
Dunfield and Haas (2009) Metaplasticity governs natural experience-driven plasticity of nascent embryonic brain circuits. Neuron. 64:240
PMID: 19874791

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Pancuronium dibromide

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References

Citations (2)

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