Pamoic acid disodium salt

Name: Pamoic acid disodium salt
Brand: Tocris Bioscience
SKU: 4298

Tocris Bioscience, part of Bio-Techne | Catalog # 4298

COA / SDS

GPR35 agonist

Discontinued Product

4298 has been discontinued. View all Orphan 7-TM Receptor Agonists products.

Key Product Details

Description:	GPR35 agonist
Chemical Name:	4,4'-Methylenebis(3-hydroxy-2-naphthalenecarboxylic acid) disodium salt
Purity:	≥99% (HPLC)
Molecular Weight:	432.33

View Full Technical Details for Pamoic acid disodium salt

Technical Data
Citations

Biological Activity for Pamoic acid disodium salt

Pamoic acid disodium salt is a GPR35 agonist. Induces GPR35 internalization and activates ERK1/2 (EC₅₀ values are 22 and 65 nM respectively). Mediates recruitment of β-arrestin2 to GPR35. Also exhibits antinociceptive effects in a mouse model of visceral pain.

Technical Data for Pamoic acid disodium salt

M. Wt	432.33
Formula	C₂₃H₁₄Na₂O₆
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	6640-22-8
PubChem ID	2723841
InChi Key	YGLLICRFEVEWOZ-UHFFFAOYSA-L
Smiles	[Na+].[Na+].OC1=C(CC2=C3C=CC=CC3=CC(C([O-])=O)=C2O)C2=CC=CC=C2C=C1C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Pamoic acid disodium salt

References are publications that support the biological activity of the product.

Jenkins Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J.Pharmacol.Exp.Ther. 2012 PMID: 22967846
Zhao Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol.Pharmacol. 2010 PMID: 20826425

Pamoic acid disodium salt

Tocris Bioscience, part of Bio-Techne | Catalog # 4298

Key Product Details

Biological Activity for Pamoic acid disodium salt

Technical Data for Pamoic acid disodium salt

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Pamoic acid disodium salt

Product Documents for Pamoic acid disodium salt

COA

Certificate of Analysis

SDS

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