PAF (C16) is an endogenous platelet-activating factor (PAF) and ligand for PAF receptors. Produced by inflammatory cells and a potent chemoattractant for polymorphonuclear neutrophils. Induces increased vascular permeability.

Product Specifications

Molecular Weight

523.68

Formula

C₂₆H₅₄NO₇P

Storage

Store at -20°C

Chemical Name

(7R)-7-(Acetyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium-4-oxide

CAS Number

74389-68-7

PubChem ID

108156

InChI Key

HVAUUPRFYPCOCA-AREMUKBSSA-N

SMILES

CC(O[C@@H](COP(OCC[N+](C)(C)C)([O-])=O)COCCCCCCCCCCCCCCCC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	52.37	100

Preparing Stock Solutions for PAF (C16)

The following data is based on the product molecular weight 523.68

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.91 mL	9.55 mL	19.10 mL
5 mM	0.38 mL	1.91 mL	3.82 mL
10 mM	0.19 mL	0.95 mL	1.91 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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Background References

References are publications that support the biological activity of the product.

Archer Actions of platelet activating factor (PAF) homologues and their combinations on neutrophil chemokinesis and cutaneous inflammatory responses in man. J.Invest.Dermatol. 1988 PMID: 3385217
Handa Vasorelaxant effect of C16-PAF and C18-PAF on renal blood flow and systemic blood pressure in the anesthetized rat. Life Sci. 1991 PMID: 1875784
Oda Molecular species of platelet-activating factor generated by human neutrophils challenged with ionophore A23187. J.Immunol. 1985 PMID: 3917470

PAF (C16)

Tocris Bioscience, part of Bio-Techne | Catalog # 2940

Key Product Details

Description

Alternative Names

View all Platelet-activating Factor (PAF) Receptor Agonists »

Product Description