PA Nic

Tocris Bioscience, part of Bio-Techne | Catalog # 6700

Caged nicotine; photoactivated by one-photon and two-photon excitation
Discontinued Product
6700 has been discontinued. View all Caged Compounds products.

Key Product Details

Description

Caged nicotine; photoactivated by one-photon and two-photon excitation

View all Caged Compounds »

Product Description

PA Nic is a coumarin-caged nicotine. Releases nicotine when exposed to 390 ± 10 nm wavelength light (λmax = 404 nm). Suitable for two-photon uncaging at <900 nm (Maximum two-photon cross-section at 810 nm). Extinction coefficient (ε) 17,400 M-1cm-1. Evokes nicotinic currents in mouse brain slices under one and two-photon activation conditions.

Product Specifications

Molecular Weight

679.52

Formula

C24H26N3O6.C2F3O2.C2HF3O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(1S,2S)-1-((7-(Bis(carboxymethyl)amino)-2-oxo-2H-chromen-4-yl)methyl)-1-methyl-2-(pyridin-3-yl)pyrrolidin-1-ium ditrifluoroacetate

SMILES

C[N@@+]1(CC2=CC(OC3=C2C=CC(N(CC(O)=O)CC(O)=O)=C3)=O)CCC[C@H]1C4=CC=CN=C4.OC(C(F)(F)F)=O.[O-]C(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 16.99 25
DMSO 16.99 25

Preparing Stock Solutions for PA Nic

The following data is based on the product molecular weight 679.52

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 5.89 mL 29.43 mL 58.87 mL
1.25 mM 1.18 mL 5.89 mL 11.77 mL
2.5 mM 0.59 mL 2.94 mL 5.89 mL
12.5 mM 0.12 mL 0.59 mL 1.18 mL

Calculators

Molarity Calculator

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Dilution Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for PA Nic

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PA Nic

For research use only

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