P1

Name: P1
Brand: Tocris Bioscience
SKU: 5127

Tocris Bioscience, part of Bio-Techne | Catalog # 5127

Citations (4)

COA / SDS

Protein disulfide isomerase (PDI) inhibitor

Discontinued Product

5127 has been discontinued. View all Protein Disulphide Isomerase Inhibitors products.

Key Product Details

Description:	Protein disulfide isomerase (PDI) inhibitor
Chemical Name:	N-[(1,1-Dimethylethoxy)carbonyl]-L-phenylalanyl-O-(ethenylsulfonyl)-N-4-pentyn-1-yl-L-tyrosinamide
Purity:	≥98% (HPLC)
Molecular Weight:	583.7

View Full Technical Details for P1

Technical Data
Citations

Biological Activity for P1

P1 is a protein disulfide isomerase (PDI) inhibitor (IC₅₀ = 1.7 μM). Inhibits proliferation of numerous cancer cell lines. Cell permeable.

Technical Data for P1

M. Wt	583.7
Formula	C₃₀H₃₇N₃O₇S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1461648-55-4
PubChem ID	91826082
InChi Key	RNMDSOKRNOMQFX-UIOOFZCWSA-N
Smiles	O=[C@@](NCCCC#C)[C@@H](NC([C@@H](NC(OC(C)(C)C)=O)CC2=CC=CC=C2)=O)CC1=CC=C(OS(C=C)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for P1

References are publications that support the biological activity of the product.

Xu Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization. PLoS One 2013 PMID: 24098548
Ge Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase ACS Chem.Biol. 2013 PMID: 24070012

P1

Tocris Bioscience, part of Bio-Techne | Catalog # 5127

Key Product Details

Biological Activity for P1

Technical Data for P1

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for P1

Product Documents for P1

COA

Certificate of Analysis

SDS

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