Ozagrel hydrochloride

Name: Ozagrel hydrochloride
Brand: Tocris Bioscience
SKU: 1510

Catalog # 1510 | Tocris Bioscience a Bio-Techne Brand

Citations (2)

COA / SDS

Selective thromboxane A2 synthetase inhibitor

Discontinued Product

1510 has been discontinued. View all Additional Prostanoid Receptor Compounds products.

Key Product Details

Description:	Selective thromboxane A₂ synthetase inhibitor
Alternative Names:	OKY 046
Chemical Name:	(2E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	264.71

View Full Technical Details for Ozagrel hydrochloride

Technical Data
Citations (2) / Reviews

Biological Activity for Ozagrel hydrochloride

Ozagrel hydrochloride is a potent and selective inhibitor of thromboxane (TXA₂) synthetase (IC₅₀ = 4 nM). Does not inhibit prostacyclin (PGI₂) synthetase, cyclooxygenase or PGE₂ isomerase (IC₅₀ > 1 mM). Inhibits platelet aggregation in vitro and arachidonate-induced arterial contraction in vivo.

Technical Data for Ozagrel hydrochloride

M. Wt	264.71
Formula	C₁₃H₁₂N₂O₂.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	78712-43-3
PubChem ID	6438130
InChi Key	CWKFWBJJNNPGAM-IPZCTEOASA-N
Smiles	Cl[H].OC(=O)\C=C\C1=CC=C(CN2C=CN=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Ozagrel hydrochloride

References are publications that support the biological activity of the product.

Shinagawa Participation of thromboxane A₂ in the cough response in guinea-pigs: antitussive effect of ozagrel. Br.J.Pharmacol. 2000 PMID: 10991919
Hiraku Pharmacological studies on the TXA₂ synthetase inhibitor (E)-3-[p-(1H-imidazol-1ylmethyl)phenyl]-2-propenoic acid (OKY-046). Jpn.J.Pharmacol. 1986 PMID: 3093741
Naito Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets. Eur.J.Pharmacol. 1983 PMID: 6413227

Citations for Ozagrel hydrochloride (2)

Showing 1 - 2 of 2 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Ozagrel hydrochloride include:

Wong et al. (2009) Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res. 104:228
PMID: 19096033
Rancillac et al. (2006) Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum. Proc Natl Acad Sci U S A. 26:6997
PMID: 16807329

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