OXF BD 02

Name: OXF BD 02
Brand: Tocris Bioscience
SKU: 4928

Tocris Bioscience, part of Bio-Techne | Catalog # 4928

COA / SDS

Selective BRD4(1) inhibitor

Discontinued Product

4928 has been discontinued. View all Bromodomain Inhibitors products.

Key Product Details

Description:	Selective BRD4(1) inhibitor
Chemical Name:	3-(3,5-Dimethyl-4-isoxazolyl)-5-hydroxy-α-phenylbenzenemethanol
Purity:	≥98% (HPLC)
Molecular Weight:	295.33

View Full Technical Details for OXF BD 02

Technical Data
Citations

Biological Activity for OXF BD 02

OXF BD 02 is a selective inhibitor of the first bromodomain of BRD4 (BRD4(1)) (IC₅₀ = 382 nM). Exhibits 2-3-fold selectivity for BRD4(1) over the CBP bromodomain and has little affinity for a range of other bromodomains. Reduces viability of lung adenocarcinoma cell lines and attenuates proliferation of MV-4-11 leukemia cells. Cell permeable.

Licensing Information

Sold with the agreement of the University of Oxford

Technical Data for OXF BD 02

M. Wt	295.33
Formula	C₁₈H₁₇NO₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1429129-68-9
PubChem ID	56929801
InChi Key	FEQUIPXIENTMJN-UHFFFAOYSA-N
Smiles	OC1=CC(C2=C(C)ON=C2C)=CC(C(O)C3=CC=CC=C3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for OXF BD 02

References are publications that support the biological activity of the product.

Hewings Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J.Med.Chem. 2013 PMID: 23517011
Hewings 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands. J.Med.Chem. 2011 PMID: 21851057