OXF BD 02
Tocris Bioscience, part of Bio-Techne | Catalog # 4928
Selective BRD4(1) inhibitor
Discontinued Product
4928 has been discontinued.
View all Bromodomain Inhibitors products.
Product Description
OXF BD 02 is a selective inhibitor of the first bromodomain of BRD4 (BRD4(1)) (IC50 = 382 nM). Exhibits 2-3-fold selectivity for BRD4(1) over the CBP bromodomain and has little affinity for a range of other bromodomains. Reduces viability of lung adenocarcinoma cell lines and attenuates proliferation of MV-4-11 leukemia cells. Cell permeable.Licensing Information
Sold with the agreement of the University of OxfordProduct Specifications
Molecular Weight
295.33
Formula
C18H17NO3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-(3,5-Dimethyl-4-isoxazolyl)-5-hydroxy-α-phenylbenzenemethanol
CAS Number
1429129-68-9
PubChem ID
56929801
InChI Key
FEQUIPXIENTMJN-UHFFFAOYSA-N
SMILES
OC1=CC(C2=C(C)ON=C2C)=CC(C(O)C3=CC=CC=C3)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.53 | 100 | |
| Ethanol | 2.95 | 10 with gentle warming |
Preparing Stock Solutions
for OXF BD 02
The following data is based on the product molecular weight 295.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.39 mL | 16.93 mL | 33.86 mL |
| 5 mM | 0.68 mL | 3.39 mL | 6.77 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.39 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hewings Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J.Med.Chem. 2013 PMID: 23517011
- Hewings 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands. J.Med.Chem. 2011 PMID: 21851057
Product Specific Notices for OXF BD 02
For research use only
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