Org 12962 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3585
Selective 5-HT2C agonist
Discontinued Product
3585 has been discontinued.
View all 5-HT2C Receptor Agonists products.
Product Description
Selective 5-HT2C receptor agonist (pEC50 values are 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2B respectively). Displays antiaversive effects in a rat model of panic-like anxiety.Product Specifications
Molecular Weight
302.12
Formula
C10H11ClF3N3.HCl
Storage
Desiccate at RT
Purity
≥99% (HPLC)
Chemical Name
1-[6-Chloro-5-trifluoromethyl)-2-pyridinyl]-piperazine hydrochloride
CAS Number
210821-63-9
PubChem ID
9796407
InChI Key
FVDILXYXZAAJOS-UHFFFAOYSA-N
SMILES
ClC1=NC(N2CCNCC2)=CC=C1C(F)(F)F.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 15.11 | 50 | |
| DMSO | 30.21 | 100 |
Preparing Stock Solutions
for Org 12962 hydrochloride
The following data is based on the product molecular weight 302.12
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.31 mL | 16.55 mL | 33.10 mL |
| 5 mM | 0.66 mL | 3.31 mL | 6.62 mL |
| 10 mM | 0.33 mL | 1.65 mL | 3.31 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Porter Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br.J.Pharmacol. 1999 PMID: 10498829
- Halford Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Curr.Drug Targets 2005 PMID: 15777190
- Jenck Antiaversive effects of 5-HT2C receptor agonists and fluox. in a model of panic-like anxiety in rats. Eur.Neuropsychopharmacol. 1998 PMID: 9716307
Product Specific Notices for Org 12962 hydrochloride
For research use only
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