Oncrasin 1
Tocris Bioscience, part of Bio-Techne | Catalog # 3427
Induces abnormal nuclear aggregation of PKCι; proapoptotic
Discontinued Product
3427 has been discontinued.
View all Additional Protein Kinase C Compounds products.
Key Product Details
Description
Induces abnormal nuclear aggregation of PKCι; proapoptotic
Product Description
Oncrasin 1 is a proapoptotic agent that induces abnormal nuclear aggregation of PKCι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo.Product Specifications
Molecular Weight
269.73
Formula
C16H12ClNO
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde
CAS Number
75629-57-1
PubChem ID
872445
InChI Key
ZDRQMXCSSAPUMM-UHFFFAOYSA-N
SMILES
O=CC2=CN(CC3=CC=C(Cl)C=C3)C1=CC=CC=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.97 | 100 | |
| Ethanol | 6.74 | 25 |
Preparing Stock Solutions
for Oncrasin 1
The following data is based on the product molecular weight 269.73
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.71 mL | 18.54 mL | 37.07 mL |
| 5 mM | 0.74 mL | 3.71 mL | 7.41 mL |
| 10 mM | 0.37 mL | 1.85 mL | 3.71 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Guo Identification of a small molecule with synthetic lethality for k-Ras and protein kinase C iota. Cancer Res.
- Guo Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1). Mol.Cancer Ther. 2009 PMID: 19208825
Product Specific Notices for Oncrasin 1
For research use only
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