Olmesartan

Name: Olmesartan
Brand: Tocris Bioscience
SKU: 4616

Tocris Bioscience, part of Bio-Techne | Catalog # 4616

Citations (5)

COA / SDS

Potent AT1 antagonist

Discontinued Product

4616 has been discontinued. View all Angiotensin AT1 Receptor Antagonists products.

Key Product Details

Description:	Potent AT₁ antagonist
Chemical Name:	4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
Purity:	≥99% (HPLC)
Molecular Weight:	446.5

View Full Technical Details for Olmesartan

Technical Data
Citations

Biological Activity for Olmesartan

Olmesartan is a potent angiotensin II type I (AT₁) receptor antagonist (IC₅₀ = 6.7 nM at hAT₁ receptors). Improves cognitive function in a mouse model of hypertension- and hyperlipidemia-associated cognitive decline; ameliorates arterial stiffness in a rat model of chronic renal failure.

Compound Libraries for Olmesartan

Olmesartan is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Olmesartan

M. Wt	446.5
Formula	C₂₄H₂₆N₆O₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	144689-24-7
PubChem ID	158781
InChi Key	VTRAEEWXHOVJFV-UHFFFAOYSA-N
Smiles	CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Olmesartan

References are publications that support the biological activity of the product.

Chuang Effects of olmes. on arterial stiffness in rats with chronic renal failure. Cardiovasc.Diabetol. 2012 PMID: 22694778
Ojima In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J.Pharmacol.Exp.Ther. 2011 PMID: 21123673
Mogi Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by the angiotensin receptor blocker, olmes. Neuropharmacology 2007 PMID: 18028965