Ocinaplon

Name: Ocinaplon
Brand: Tocris Bioscience
SKU: 4410

Tocris Bioscience a Bio-Techne Brand

Catalog # 4410

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Key Product Details

Description:	GABA_A modulator; anxiolytic
Chemical Name:	2-Pyridinyl[7-(4-pyridinyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone
Purity:	≥98% (HPLC)
Molecular Weight:	301.3

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Biological Activity for Ocinaplon

Ocinaplon is a modulator of GABA_A receptors. Displays modest selectivity for GABA_A α₁ receptors; displays partial agonist activity at α2-, α3- and α5-containing receptors. Exhibits anxiolytic activity.

Technical Data for Ocinaplon

M. Wt	301.3
Formula	C₁₇H₁₁N₅O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	96604-21-6
PubChem ID	216456
InChi Key	OQJFBUOFGHPMSR-UHFFFAOYSA-N
Smiles	O=C(C4=CC=CC=N4)C2=C1N=CC=C(C3=CC=NC=C3)N1N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ocinaplon

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	2eq.HCl	30.13	100
	DMSO	3.01	10

Preparing Stock Solutions for Ocinaplon

The following data is based on the product molecular weight 301.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.32 mL	16.59 mL	33.19 mL
5 mM	0.66 mL	3.32 mL	6.64 mL
10 mM	0.33 mL	1.66 mL	3.32 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

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Reconstitution Calculator

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References for Ocinaplon

References are publications that support the biological activity of the product.

Mirza Comparative cue generalization profiles of L-838,417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, ZopiC., and various benzodiazepines in chlordiazep. and zol. drug discrimination. J.Pharmacol.Exp.Ther. 2006 PMID: 16339395
Rupprecht GABA_A receptors as targets for novel anxiolytic drugs. World J.Biol.Psychiatry 2006 PMID: 17071543
Lippa Selective anxiolysis produced by ocinaplon, a GABA_A receptor modulator. Proc.Natl.Acad.Sci.USA 2005 PMID: 15870187

Citations for Ocinaplon

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Ocinaplon

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Biological Activity for Ocinaplon

Technical Data for Ocinaplon

Solubility for Ocinaplon

Preparing Stock Solutions for Ocinaplon

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Ocinaplon

Citations for Ocinaplon

Product Documents for Ocinaplon

COA

Certificate of Analysis

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