Ocinaplon
Tocris Bioscience, part of Bio-Techne | Catalog # 4410
GABAA modulator; anxiolytic
Discontinued Product
4410 has been discontinued.
View all GABA-A Receptor Modulators products.
Product Description
Ocinaplon is a modulator of GABAA receptors. Displays modest selectivity for GABAA α1 receptors; displays partial agonist activity at α2-, α3- and α5-containing receptors. Exhibits anxiolytic activity.Product Specifications
Molecular Weight
301.30
Formula
C17H11N5O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-Pyridinyl[7-(4-pyridinyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone
CAS Number
96604-21-6
PubChem ID
216456
InChI Key
OQJFBUOFGHPMSR-UHFFFAOYSA-N
SMILES
O=C(C4=CC=CC=N4)C2=C1N=CC=C(C3=CC=NC=C3)N1N=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 2eq.HCl | 30.13 | 100 | |
| DMSO | 3.01 | 10 |
Preparing Stock Solutions
for Ocinaplon
The following data is based on the product molecular weight 301.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.32 mL | 16.59 mL | 33.19 mL |
| 5 mM | 0.66 mL | 3.32 mL | 6.64 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.32 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lippa Selective anxiolysis produced by ocinaplon, a GABAA receptor modulator. Proc.Natl.Acad.Sci.USA 2005 PMID: 15870187
- Rupprecht GABAA receptors as targets for novel anxiolytic drugs. World J.Biol.Psychiatry 2006 PMID: 17071543
- Mirza Comparative cue generalization profiles of L-838,417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, ZopiC., and various benzodiazepines in chlordiazep. and zol. drug discrimination. J.Pharmacol.Exp.Ther. 2006 PMID: 16339395
Product Specific Notices for Ocinaplon
For research use only
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