O-Phospho-L-serine
Tocris Bioscience, part of Bio-Techne | Catalog # 0238
Group III mGlu agonist
Discontinued Product
0238 has been discontinued.
View all Group III mGluR Agonists products.
Key Product Details
Description
Group III mGlu agonist
Alternative Names
L-SOP
Product Description
O-Phospho-L-serine is a group III metabotropic glutamate receptor agonist; analog of L-AP4 (Cat. No. 0103). Neuroprotective against excitotoxicity in cortical cell cultures. Inhibits proliferation and enhances neuronal differentiation in progenitor cells.Product Specifications
Molecular Weight
185.07
Formula
C3H8NO6P
Storage
Store at RT
Chemical Name
L-Serine-O-phosphate
CAS Number
407-41-0
PubChem ID
68841
InChI Key
BZQFBWGGLXLEPQ-REOHCLBHSA-N
SMILES
[H][C@@](COP(O)(O)=O)(N)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 18.51 | 100 |
Preparing Stock Solutions
for O-Phospho-L-serine
The following data is based on the product molecular weight 185.07
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.40 mL | 27.02 mL | 54.03 mL |
| 5 mM | 1.08 mL | 5.40 mL | 10.81 mL |
| 10 mM | 0.54 mL | 2.70 mL | 5.40 mL |
| 50 mM | 0.11 mL | 0.54 mL | 1.08 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Park Expanding the genetic code of Escherichia coli with phosphoserine. Science 2011 PMID: 21868676
- Yang A chemical biology route to site-specific authentic protein modifications. Science 2016 PMID: 27708052
- Saxe A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation. Chem.Biol. 2007 PMID: 17884634
- Thoreson and Ulphani Pharmacology of selective and non-selective metabotropic glutamate receptor agonists at L-AP4 receptors in ON bipolar cells. Brain Res. 1995 PMID: 7796182
- Eriksen and Thomsen [3H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a. Br.J.Pharmacol. 1995 PMID: 8719808
- Bruno Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures. Eur.J.Pharmacol. 1996 PMID: 8880068
Product Specific Notices for O-Phospho-L-serine
For research use only
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