O-2050

Name: O-2050
Brand: Tocris Bioscience
SKU: 1655

Tocris Bioscience, part of Bio-Techne | Catalog # 1655

Citations (6)

COA / SDS

Putative CB1 antagonist; displays mixed activity at CB receptors

Discontinued Product

1655 has been discontinued. View all Cannabinoid R1/CB1 Antagonists products.

Key Product Details

Description:	Putative CB₁ antagonist; displays mixed activity at CB receptors
Chemical Name:	(6aR,10aR)-1-Hydroxy-3-(1-Methanesulfonylamino-4-hexyn-6-yl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran
Purity:	≥97% (HPLC)
Molecular Weight:	417.56

View Full Technical Details for O-2050

Technical Data
Citations

Biological Activity for O-2050

O-2050 is an originally defined as a high affinity cannabinoid CB₁ receptor silent antagonist. Acts as a partial agonist in inhibiting forksolin-induced cyclic AMP stimulation (EC₅₀ = 40.4 nM). Decreases food intake and stimulates locomotor activity in rodents. Antagonizes effects of CP55,940 (Cat. No. 0949) in vitro.

Licensing Information

Sold under license from VCU-IPF

Technical Data for O-2050

M. Wt	417.56
Formula	C₂₃H₃₁NO₄S
Storage	Store at -80°C
Purity	≥97% (HPLC)
CAS Number	1883545-42-3
PubChem ID	16102146
InChi Key	DJTGGIYZQHHLGJ-RTBURBONSA-N
Smiles	OC1=CC(CC#CCCCNS(=O)(C)=O)=CC3=[C@@]1[C@@H]2CC(C)=CC[C@H]2[C@@](C)(C)O3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for O-2050

References are publications that support the biological activity of the product.

Martin Agonists and silent antagonists in a series of cannabinoid sulfonamides. Symposium on the Cannabinoids, International Canna
Wiley Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB₁ receptor antagonist. Eur.J.Pharmacol. 2011 PMID: 21114999
Gardner and Mallet Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist.' Eur.J.Pharmacol. 2006 PMID: 16380113