NVP DPP 728 dihydrochloride

Name: NVP DPP 728 dihydrochloride
Brand: Tocris Bioscience
SKU: 3506

Tocris Bioscience, part of Bio-Techne | Catalog # 3506

Citations (3)

COA / SDS

Potent, orally active dipeptidyl peptidase IV (DPP-IV) inhibitor

Discontinued Product

3506 has been discontinued. View all DPPIV/CD26 Inhibitors products.

Key Product Details

Description:	Potent, orally active dipeptidyl peptidase IV (DPP-IV) inhibitor
Chemical Name:	6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitrile dihydrochloride
Purity:	≥97% (HPLC)
Molecular Weight:	371.27

View Full Technical Details for NVP DPP 728 dihydrochloride

Technical Data
Citations

Biological Activity for NVP DPP 728 dihydrochloride

Potent, orally active dipeptidyl peptidase (DPP)-IV inhibitor (K_i = 11 nM, IC₅₀ = 14 nM) that displays > 15 000-fold selectivity over DPP-II and a range of proline-cleaving proteases. Exhibits antidiabetic activity in vivo; improves glucose tolerance, increases glucagon-like peptide 1 (GLP-1) and insulin levels, augments insulin secretion and GLUT2 levels, and reduces (preserves) islet size.

Technical Data for NVP DPP 728 dihydrochloride

M. Wt	371.27
Formula	C₁₅H₁₈N₆O.2HCl
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	207556-62-5
PubChem ID	9799555
InChi Key	VNACOBVZDCLAEV-GXKRWWSZSA-N
Smiles	O=C(N2CCC[C@H]2C#N)CNCCNC1=NC=C(C#N)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for NVP DPP 728 dihydrochloride

References are publications that support the biological activity of the product.

Reimer Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice. Eur.J.Endocrinol. 2002 PMID: 11980629
Mitani Dipeptidyl peptidase IV inhibitor NVP-DPP728 ameliorates early Ins response and glucose tolerance in aged rats but not in aged Fischer 344 rats lacking its enzyme activity. Jpn.J.Pharmacol. 2002 PMID: 12046989
Hughes NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)-pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV. Biochemistry 1999 PMID: 10512614

NVP DPP 728 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 3506

Key Product Details

Biological Activity for NVP DPP 728 dihydrochloride

Technical Data for NVP DPP 728 dihydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for NVP DPP 728 dihydrochloride

Product Documents for NVP DPP 728 dihydrochloride

COA

Certificate of Analysis

SDS

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