NVP DPP 728 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3506
Potent, orally active dipeptidyl peptidase IV (DPP-IV) inhibitor
Discontinued Product
3506 has been discontinued.
View all DPPIV/CD26 Inhibitors products.
Key Product Details
Description
Potent, orally active dipeptidyl peptidase IV (DPP-IV) inhibitor
Product Description
Potent, orally active dipeptidyl peptidase (DPP)-IV inhibitor (Ki = 11 nM, IC50 = 14 nM) that displays > 15 000-fold selectivity over DPP-II and a range of proline-cleaving proteases. Exhibits antidiabetic activity in vivo; improves glucose tolerance, increases glucagon-like peptide 1 (GLP-1) and insulin levels, augments insulin secretion and GLUT2 levels, and reduces (preserves) islet size.Product Specifications
Molecular Weight
371.27
Formula
C15H18N6O.2HCl
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitrile dihydrochloride
CAS Number
207556-62-5
PubChem ID
9799555
InChI Key
VNACOBVZDCLAEV-GXKRWWSZSA-N
SMILES
O=C(N2CCC[C@H]2C#N)CNCCNC1=NC=C(C#N)C=C1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 37.13 | 100 | |
| DMSO | 37.13 | 100 |
Preparing Stock Solutions
for NVP DPP 728 dihydrochloride
The following data is based on the product molecular weight 371.27
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.69 mL | 13.47 mL | 26.93 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.39 mL |
| 10 mM | 0.27 mL | 1.35 mL | 2.69 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Reimer Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice. Eur.J.Endocrinol. 2002 PMID: 11980629
- Mitani Dipeptidyl peptidase IV inhibitor NVP-DPP728 ameliorates early Ins response and glucose tolerance in aged rats but not in aged Fischer 344 rats lacking its enzyme activity. Jpn.J.Pharmacol. 2002 PMID: 12046989
- Hughes NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)-pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV. Biochemistry 1999 PMID: 10512614
Product Specific Notices for NVP DPP 728 dihydrochloride
For research use only
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