NU 7026
Tocris Bioscience, part of Bio-Techne | Catalog # 2828
Selective DNA-PK inhibitor
Discontinued Product
2828 has been discontinued.
View all DNA-dependent Protein Kinase Inhibitors products.
Key Product Details
Description
Selective DNA-PK inhibitor
Product Description
NU 7026 is an ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC50 values are 0.23, 13.0, > 100 and > 100 μM for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.Product Specifications
Molecular Weight
281.31
Formula
C17H15NO3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one
CAS Number
154447-35-5
PubChem ID
9860529
InChI Key
KKTZALUTXUZPSN-UHFFFAOYSA-N
SMILES
O=C2C1=CC=C3C(C=CC=C3)=C1OC(N4CCOCC4)=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.81 | 10 |
Preparing Stock Solutions
for NU 7026
The following data is based on the product molecular weight 281.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.55 mL | 177.74 mL | 355.48 mL |
| 0.5 mM | 7.11 mL | 35.55 mL | 71.10 mL |
| 1 mM | 3.55 mL | 17.77 mL | 35.55 mL |
| 5 mM | 0.71 mL | 3.55 mL | 7.11 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Amrein Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase. J.Pharmacol.Exp.Ther. 2007 PMID: 17351105
- Hollick 2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-dependent protein kinase (DNA-PK). Bioorg.Med.Chem.Letts. 2003 PMID: 12941339
- Veuger Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-I. Cancer Res. 2003 PMID: 14522929
Product Specific Notices for NU 7026
For research use only
Loading...
Loading...
Loading...