NU 7026

Name: NU 7026
Brand: Tocris Bioscience
SKU: 2828
Rating: 5 (1 reviews)

Catalog # 2828 | Tocris Bioscience a Bio-Techne Brand

(1)

Citations (14)

COA / SDS

Selective DNA-PK inhibitor

Key Product Details

Description:	Selective DNA-PK inhibitor
Chemical Name:	2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	281.31

View Full Technical Details for NU 7026

Technical Data
Citations (14) / Reviews (1)

Biological Activity for NU 7026

NU 7026 is an ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC₅₀ values are 0.23, 13.0, > 100 and > 100 μM for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.

Technical Data for NU 7026

M. Wt	281.31
Formula	C₁₇H₁₅NO₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	154447-35-5
PubChem ID	9860529
InChi Key	KKTZALUTXUZPSN-UHFFFAOYSA-N
Smiles	O=C2C1=CC=C3C(C=CC=C3)=C1OC(N4CCOCC4)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NU 7026

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2.81	10

Preparing Stock Solutions for NU 7026

The following data is based on the product molecular weight 281.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.55 mL	177.74 mL	355.48 mL
0.5 mM	7.11 mL	35.55 mL	71.10 mL
1 mM	3.55 mL	17.77 mL	35.55 mL
5 mM	0.71 mL	3.55 mL	7.11 mL

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Reconstitution Calculator

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References for NU 7026

References are publications that support the biological activity of the product.

Amrein Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase. J.Pharmacol.Exp.Ther. 2007 PMID: 17351105
Veuger Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-I. Cancer Res. 2003 PMID: 14522929
Hollick 2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-dependent protein kinase (DNA-PK). Bioorg.Med.Chem.Letts. 2003 PMID: 12941339

Citations for NU 7026 (14)

Showing 1 - 10 of 14 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for NU 7026 include:

Jaiswal et al. (2017) ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration. EMBO J. 36:2161
PMID: 28607002
You et al. (2015) Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema. Elife. 4
PMID: 26437452
Dolman et al. (2015) DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells. PLoS One. 10:e0145744
PMID: 26716839
Nakahara et al. (2015) Activation of NF-κB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1. Chembiochem. 89:5040
PMID: 25717108
Rodgers et al. (2015) Spatio-temporal regulation of RAG2 following genotoxic stress. DNA Repair (Amst). 27:19
PMID: 25625798
Allen et al. (2015) DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation. Front Oncol. 5:260
PMID: 26697402
Yousefzadeh et al. (2014) Mechanism of suppression of chromosomal instability by DNA polymerase POLQ. PLoS Genet. 10:e1004654
PMID: 25275444
Fard et al. (2013) The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway. Cell Cycle. 13:408
PMID: 24247150
Sultana et al. (2013) Targeting XRCC1 deficiency in breast cancer for personalized therapy. Cancer Res. 73:1621
PMID: 23253910
Petruccelli et al. (2013) Expression of leukemia-associated fusion proteins increases sensitivity to histone deacetylase inhibitor-induced DNA damage and apoptosis. Mol Cancer Ther. 12:1591
PMID: 23536727
Tang et al. (2012) Detection of early Abl kinase activation after ionizing radiation by using a peptide biosensor. J Neurosci. 13:665
PMID: 22334513
Kanai et al. (2012) Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells. J Natl Cancer Inst. 104:42
PMID: 22173583
Ando et al. (2012) PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. Mol Cell. 47:681
PMID: 22854598
Bohgaki et al. (2011) Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. PLoS Genet. 7:e1001381
PMID: 21552324

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Customer Reviews for NU 7026 (1)

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DNAPKi

Name: Isabelle Cristine da Costa

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: U2OS

I used the DNA-PK inhibitor (NU7026) to treat human osteosarcoma cells (U2OS) and assessed if the inhibition worked by blotting for pDNA-PKcs (S2056). The inhibitor works extremely well!

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