NU 7026

Name: NU 7026
Brand: Tocris Bioscience
SKU: 2828
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2828

(1)

Citations (43)

COA / SDS

Selective DNA-PK inhibitor

Key Product Details

Description:	Selective DNA-PK inhibitor
Chemical Name:	2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	281.31

View Full Technical Details for NU 7026

Technical Data
Citations / Reviews (1)

Biological Activity for NU 7026

NU 7026 is an ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC₅₀ values are 0.23, 13.0, > 100 and > 100 μM for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.

Technical Data for NU 7026

M. Wt	281.31
Formula	C₁₇H₁₅NO₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	154447-35-5
PubChem ID	9860529
InChi Key	KKTZALUTXUZPSN-UHFFFAOYSA-N
Smiles	O=C2C1=CC=C3C(C=CC=C3)=C1OC(N4CCOCC4)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NU 7026

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2.81	10

Preparing Stock Solutions for NU 7026

The following data is based on the product molecular weight 281.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.55 mL	177.74 mL	355.48 mL
0.5 mM	7.11 mL	35.55 mL	71.10 mL
1 mM	3.55 mL	17.77 mL	35.55 mL
5 mM	0.71 mL	3.55 mL	7.11 mL

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References for NU 7026

References are publications that support the biological activity of the product.

Amrein Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase. J.Pharmacol.Exp.Ther. 2007 PMID: 17351105
Hollick 2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-dependent protein kinase (DNA-PK). Bioorg.Med.Chem.Letts. 2003 PMID: 12941339
Veuger Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-I. Cancer Res. 2003 PMID: 14522929