NS 383

Product Description

NS 383 is an ASIC blocker (IC₅₀ values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC₅₀ value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC₅₀ values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC_5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.

Solubility

Preparing Stock Solutions for NS 383

The following data is based on the product molecular weight 321.37

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	62.23 mL	311.17 mL	622.34 mL
0.25 mM	12.45 mL	62.23 mL	124.47 mL
0.5 mM	6.22 mL	31.12 mL	62.23 mL
2.5 mM	1.24 mL	6.22 mL	12.45 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Munro NS383 Selectively inhibits acid-sensing ion channels containing 1a and 3 subunits to reverse inflammatory and neuropathic hyperalgesia in rats. CNS Neurosci.Ther. 2016 PMID: 26663905