Noscapine hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 1697

Tubulin inhibitor; induces apoptosis
Discontinued Product
1697 has been discontinued. View all Microtubule Binding Compounds products.

Key Product Details

Description

Tubulin inhibitor; induces apoptosis

View all Microtubule Binding Compounds »

Product Description

Noscapine hydrochloride is an opioid alkaloid with several actions. Binds to tubulin, arrests cells in mitosis and induces apoptosis. Antagonist at bradykinin receptors (pA2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues. Modulates IKK activation, suppressing the NF-κB signaling pathway. Blocks proliferation of human leukemia and multiple myeloma cells. Exhibits anti-inflammatory activity.

Product Specifications

Molecular Weight

449.88

Formula

C22H23NO7.HCl

Storage

Desiccate at RT

Purity

≥99% (HPLC)

Chemical Name

(3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone hydrochloride

CAS Number

912-60-7

PubChem ID

442329

InChI Key

MFLVZFXCSKVCSH-URBRKQAFSA-N

SMILES

O=C2C1=C(OC)C(OC)=CC=C1[C@]([C@]3([H])N(CCC4=C3C(OC)=C5C(OCO5)=C4)C)([H])O2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 22.49 50

Preparing Stock Solutions for Noscapine hydrochloride

The following data is based on the product molecular weight 449.88

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.45 mL 22.23 mL 44.46 mL
2.5 mM 0.89 mL 4.45 mL 8.89 mL
5 mM 0.44 mL 2.22 mL 4.45 mL
25 mM 0.09 mL 0.44 mL 0.89 mL

Calculators

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Product Documents for Noscapine hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Noscapine hydrochloride

For research use only

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