Noscapine hydrochloride

Name: Noscapine hydrochloride
Brand: Tocris Bioscience
SKU: 1697

Tocris Bioscience a Bio-Techne Brand

Catalog # 1697

Citations (1)

COA / SDS

Discontinued Product

1697 has been discontinued. View all Microtubule Binding Compounds products.

Key Product Details

Description:	Tubulin inhibitor; induces apoptosis
Chemical Name:	(3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	449.88

View Full Technical Details for Noscapine hydrochloride

Biological Activity for Noscapine hydrochloride

Noscapine hydrochloride is an opioid alkaloid with several actions. Binds to tubulin, arrests cells in mitosis and induces apoptosis. Antagonist at bradykinin receptors (pA₂ = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues. Modulates IKK activation, suppressing the NF-κB signaling pathway. Blocks proliferation of human leukemia and multiple myeloma cells. Exhibits anti-inflammatory activity.

Technical Data for Noscapine hydrochloride

M. Wt	449.88
Formula	C₂₂H₂₃NO₇.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	912-60-7
PubChem ID	442329
InChi Key	MFLVZFXCSKVCSH-URBRKQAFSA-N
Smiles	O=C2C1=C(OC)C(OC)=CC=C1[C@]([C@]3([H])N(CCC4=C3C(OC)=C5C(OCO5)=C4)C)([H])O2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Noscapine hydrochloride

References are publications that support the biological activity of the product.

Sung Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-κB signaling pathway. Cancer Res. 2010 PMID: 20354190
Landen Noscapine alters microtubule dynamics in living cells and inhibits the progression of melanoma. Cancer Res. 2002 PMID: 12124349
Mahmoudian and Mojaverian Effect of noscapine, the antitussive opioid alkaloid, on bradykinin-induced smooth muscle contraction in the isolated ileum of the guinea-pig. Acta Physiol.Hung. 2001 PMID: 12162581
Mourey [³H]Noscapine binding sites in brain: relationship to indoleamines and the phosphoinositide and adenylyl cyclase messenger systems. Mol.Pharmacol. 1992 PMID: 1331753

Citations for Noscapine hydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for Noscapine hydrochloride include:

Rennekamp et al. (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol. 12:552
PMID: 27239788

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Product Documents for Noscapine hydrochloride

COA

Certificate of Analysis

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