NNC 63-0532

Name: NNC 63-0532
Brand: Tocris Bioscience
SKU: 1780

Catalog # 1780 | Tocris Bioscience a Bio-Techne Brand

Citations (1)

COA / SDS

Potent non-peptide NOP agonist; brain penetrant

Key Product Details

Description:	Potent non-peptide NOP agonist; brain penetrant
Chemical Name:	8-(1-Naphthalenylmethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-3-acetic acid, methyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	443.54

View Full Technical Details for NNC 63-0532

Technical Data
Citations (1) / Reviews

Biological Activity for NNC 63-0532

NNC 63-0532 is a potent non-peptide agonist for the NOP receptor (EC₅₀ = 305 nM, K_i = 7.3 nM); ~ 12-fold selective over other receptors. Centrally active following systemic administration in vivo.

Compound Libraries for NNC 63-0532

NNC 63-0532 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NNC 63-0532

M. Wt	443.54
Formula	C₂₇H₂₉N₃O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	250685-44-0
PubChem ID	3906780
InChi Key	DSEIKQVUTKGLGT-UHFFFAOYSA-N
Smiles	COC(=O)CN1CN(C2=CC=CC=C2)C2(CCN(CC3=CC=C4C=CC=CC4=C3)CC2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NNC 63-0532

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	2.22	5
	DMSO	22.18	50

Preparing Stock Solutions for NNC 63-0532

The following data is based on the product molecular weight 443.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.51 mL	22.55 mL	45.09 mL
2.5 mM	0.90 mL	4.51 mL	9.02 mL
5 mM	0.45 mL	2.25 mL	4.51 mL
25 mM	0.09 mL	0.45 mL	0.90 mL

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References for NNC 63-0532

References are publications that support the biological activity of the product.

Thomsen and Hohlweg (8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]-dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist. Br.J.Pharmacol. 2000 PMID: 11053209

Citations for NNC 63-0532 (1)

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Citations are publications that use Bio-Techne products. Selected citations for NNC 63-0532 include:

Gear et al. (2014) NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids. Neuroscience. 257:139
PMID: 24188792

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