NNC 05-2090 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2747
GABA uptake inhibitor; moderately BGT-1 selective
Discontinued Product
2747 has been discontinued.
View all GABA Transporter Inhibitors products.
Key Product Details
Description
GABA uptake inhibitor; moderately BGT-1 selective
Product Description
NNC 05-2090 hydrochloride is a GABA uptake inhibitor that displays moderate selectivity for BGT-1 (mGAT-2) transporters (Ki values are 1.4, 15, 19 and 41 μM for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively). Anticonvulsive; inhibits sound-induced tonic and clonic convulsions in DBA/2 mice. Also displays affinity at α1- and D2-receptors (IC50 values are 266 and 1632 nM respectively).Product Specifications
Molecular Weight
451.01
Formula
C27H30N2O2.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride
CAS Number
184845-18-9
PubChem ID
18782760
InChI Key
WDFXPKKFSNMGOO-UHFFFAOYSA-N
SMILES
Cl.COC1=C(C=CC=C1)C1(O)CCN(CCCN2C3=C(C=CC=C3)C3=C2C=CC=C3)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.1 | 100 | |
| Ethanol | 5.64 | 12.5 |
Preparing Stock Solutions
for NNC 05-2090 hydrochloride
The following data is based on the product molecular weight 451.01
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.22 mL | 11.09 mL | 22.17 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.43 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.22 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Dalby Anticonvulsive properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1. Epilepsy Res. 1997 PMID: 9255599
- Thomsen 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter. Br.J.Pharmacol. 1997 PMID: 9134205
Product Specific Notices for NNC 05-2090 hydrochloride
For research use only
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