Nimesulide

Name: Nimesulide
Brand: tocris
SKU: 2470

Catalog # 2470

Citations (3)

Datasheet / COA / SDS

Discontinued Product

2470 has been discontinued. View all Cyclooxygenase Inhibitors products.

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Key Product Details

Description:	Cyclooxygenase-2 (COX-2) inhibitor
Alternative Names:	Flogovital, Aulin
Chemical Name:	N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
Purity:	≥99% (HPLC)
Molecular Weight:	308.31

View Full Technical Details for Nimesulide

Biological Activity

Nimesulide is a selective, orally active cyclooxygenase-2 (COX-2) inhibitor. Produces potent analgesic, anti-inflammatory and antipyretic activities in vivo. Reported to produce fewer gastrointestinal side effects than standard NSAIDs. Also inhibits sodium-dependent neutral amino acid transporter B0AT1 (SLC6A19; IC₅₀ = 23 μM).

Technical Data

M. Wt	308.31
Formula	C₁₃H₁₂N₂O₅S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	51803-78-2
PubChem ID	4495
InChi Key	HYWYRSMBCFDLJT-UHFFFAOYSA-N
Smiles	CS(=O)(=O)NC1=C(OC2=CC=CC=C2)C=C(C=C1)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	30.83	100
	ethanol	7.71	25

Preparing Stock Solutions

The following data is based on the product molecular weight 308.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.24 mL	16.22 mL	32.43 mL
5 mM	0.65 mL	3.24 mL	6.49 mL
10 mM	0.32 mL	1.62 mL	3.24 mL
50 mM	0.06 mL	0.32 mL	0.65 mL

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References

References are publications that support the biological activity of the product.

Famaey In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. Inflamm.Res. 1997 PMID: 9427063
Cullen Selective cyclooxygenase-2 inhibition by nimesulide in man. J.Pharmacol.Exp.Ther. 1998 PMID: 9808683
Pochini Nimesulide binding site in the B0AT1 (SLC6A19) amino acid transporter. Mechanism of inhibition revealed by proteoliposome transport assay and molecular modelling. Biochem.Pharmacol. 2014 PMID: 24704252

Citations (3)

Showing 1 - 3 of 3 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Nimesulide include:

Baranowska-Kuczko et al. (2014) Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries. J Neuroimmune Pharmacol. 387:477
PMID: 24682422
Anneken et al. (2013) MDMA increases glutamate release and reduces parvalbumin-positive GABAergic cells in the dorsal hippocampus of the rat: role of cyclooxygenase. Nat Commun. 8:58
PMID: 23179355
Staniaszek et al. (2010) Effects of COX-2 inhibition on spinal nociception: the role of endocannabinoids. Br J Pharmacol. 160:669
PMID: 20590570

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Product Documents

COA

Certificate of Analysis

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Nimesulide

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References

Citations (3)

Product Documents

COA

Certificate of Analysis

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