NI 42

Name: NI 42
Brand: Tocris Bioscience
SKU: 5786

Tocris Bioscience, part of Bio-Techne | Catalog # 5786

COA / SDS

High affinity BRPF inhibitor

Discontinued Product

5786 has been discontinued. View all Bromodomain Inhibitors products.

Key Product Details

Description:	High affinity BRPF inhibitor
Chemical Name:	4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	353.39

View Full Technical Details for NI 42

Technical Data
Citations

Biological Activity for NI 42

NI 42 is a high affinity BRPF inhibitor (K_d values are 40, 210 and 943 nM for BRPF1B, 2 and 3, respectively). Also exhibits modest activity at BRD9 (K_d = 1130 nM). Exhibits selectivity for BRPF over 44 other bromodomains. Orally bioavailable.

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. NI 42 is listed on the Chemical Probes website.

Technical Data for NI 42

M. Wt	353.39
Formula	C₁₈H₁₅N₃O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1884640-99-6
PubChem ID	118933132
InChi Key	BMVCSXFOQPYKKC-UHFFFAOYSA-N
Smiles	O=S(C1=CC=C(C#N)C=C1)(NC2=CC=C(N(C)C(C(C)=C3)=O)C3=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for NI 42

References are publications that support the biological activity of the product.

Igoe Design of a biased potent small molecule inhibitor of the bromodomain and PHD finger-containing (BRPF) proteins suitable for cellular and in vivo studies. J.Med.Chem 2017 PMID: 28068087

NI 42

Tocris Bioscience, part of Bio-Techne | Catalog # 5786

Key Product Details

Biological Activity for NI 42

Technical Data for NI 42

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for NI 42

Product Documents for NI 42

COA

Certificate of Analysis

SDS

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