Neuropeptide AF (human)

Name: Neuropeptide AF (human)
Brand: Tocris Bioscience
SKU: 1928

Tocris Bioscience a Bio-Techne Brand

Catalog # 1928

COA / SDS

Discontinued Product

1928 has been discontinued. View all Additional Neuropeptide FF/AF Receptor Peptides products.

Key Product Details

Description:	Endogenous NPFF₁ and NPFF₂ agonist; antiopioid neuropeptide and MRGPRA agonist
Alternative Names:	NPAF, Neuropeptide NPAF (human FMRFamide-related)
Molecular Weight:	1978.19

View Full Technical Details for Neuropeptide AF (human)

Biological Activity for Neuropeptide AF (human)

Neuropeptide AF (human) is an endogenous antiopioid neuropeptide and agonist at NPFF₁ and NPFF₂ receptors. Implicated in pain modulation and endocrine functions. May also regulate metabolism via stimulation of β-adrenoceptor expression in adipocytes. Also MRGPRA agonist

Technical Data for Neuropeptide AF (human)

M. Wt	1978.19
Formula	C₉₀H₁₃₂N₂₆O₂₅
Single Letter Sequence	AGEGLNSQFWSLAAPQRF (Modifications: Phe-18 = C-terminal amide)
Storage	Desiccate at -20°C
CAS Number	192387-38-5
PubChem ID	90488726
InChi Key	DYSIROANKWMSGC-KWFINLGMSA-N
Smiles	[H]N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Neuropeptide AF (human)

Solubility

Soluble to 1mg/ml in water

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References for Neuropeptide AF (human)

References are publications that support the biological activity of the product.

Solinski Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 2014 PMID: 24867890
Lefrere Neuropeptide AF and FF modulation of adipocyte metabolism. J.Biol.Chem. 2002 PMID: 12149260
Elshourbagy Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor. J.Biol.Chem. 2000 PMID: 10851242
Vilim Gene for pain modulatory neuropeptide FF: induction in spinal cord by noxious stimuli. Mol.Pharmacol. 1999 PMID: 10220558

Citations for Neuropeptide AF (human)

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