Neuropeptide AF (human)
Tocris Bioscience, part of Bio-Techne | Catalog # 1928
Endogenous NPFF1 and NPFF2 agonist; antiopioid neuropeptide and MRGPRA agonist
Discontinued Product
1928 has been discontinued.
View all Additional Neuropeptide FF/AF Receptor Peptides products.
Key Product Details
Description
Endogenous NPFF1 and NPFF2 agonist; antiopioid neuropeptide and MRGPRA agonist
Alternative Names
NPAF,Neuropeptide NPAF (human FMRFamide-related)
Product Description
Neuropeptide AF (human) is an endogenous antiopioid neuropeptide and agonist at NPFF1 and NPFF2 receptors. Implicated in pain modulation and endocrine functions. May also regulate metabolism via stimulation of β-adrenoceptor expression in adipocytes. Also MRGPRA agonistProduct Specifications
Molecular Weight
1978.19
Formula
C90H132N26O25
Storage
Desiccate at -20°C
CAS Number
192387-38-5
PubChem ID
90488726
InChI Key
DYSIROANKWMSGC-KWFINLGMSA-N
SMILES
[H]N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Solinski Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 2014 PMID: 24867890
- Lefrere Neuropeptide AF and FF modulation of adipocyte metabolism. J.Biol.Chem. 2002 PMID: 12149260
- Vilim Gene for pain modulatory neuropeptide FF: induction in spinal cord by noxious stimuli. Mol.Pharmacol. 1999 PMID: 10220558
- Elshourbagy Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor. J.Biol.Chem. 2000 PMID: 10851242
Product Specific Notices for Neuropeptide AF (human)
For research use only
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