Ned K

Tocris Bioscience, part of Bio-Techne | Catalog # 5976

Prevents Ca2+ oscillations in cardiomyocytes during ischemia/reperfusion; NAADP signaling inhibitor
Discontinued Product
5976 has been discontinued. View all Calcium Signaling Agents products.

Key Product Details

Description

Prevents Ca2+ oscillations in cardiomyocytes during ischemia/reperfusion; NAADP signaling inhibitor

View all Calcium Signaling Agents »

Product Description

Ned K is a NAADP inhibitor. Prevents Ca2+ oscillations in rat cardiomyocytes in vitro during simulated ischemia and reperfusion, but exhibits no significant effect on Ca2+ sparks. Significantly reduces infarct size in rat cardiac ischemia/reperfusion model in vivo.

Product Specifications

Molecular Weight

521.61

Formula

C31H31N5O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(1R,3S)-1-[3-[[4-(2-Cyanophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

CAS Number

2250019-90-8

PubChem ID

127021041

InChI Key

LMTWTJMBOFXQTH-LITSAYRRSA-N

SMILES

O=C(O)[C@H]1N[C@H](C2=CC=C(OC)C(CN3CCN(C4=CC=CC=C4C#N)CC3)=C2)C5=C(C(C=CC=C6)=C6N5)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.08 50

Preparing Stock Solutions for Ned K

The following data is based on the product molecular weight 521.61

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.83 mL 19.17 mL 38.34 mL
2.5 mM 0.77 mL 3.83 mL 7.67 mL
5 mM 0.38 mL 1.92 mL 3.83 mL
25 mM 0.08 mL 0.38 mL 0.77 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Ned K

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ned K

For research use only

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