NAV 26

Name: NAV 26
Brand: Tocris Bioscience
SKU: 4691

Tocris Bioscience, part of Bio-Techne | Catalog # 4691

Citations (6)

COA / SDS

Selective Nav1.7 channel blocker

Discontinued Product

4691 has been discontinued. View all Voltage-gated Sodium Channel Blockers products.

Key Product Details

Description:	Selective Na_v1.7 channel blocker
Chemical Name:	2,3-Dihydro-3-oxo-2-(tetrahydro-2H-pyran-4-yl)-N-[[4-(trifluoromethoxy)phenyl]methyl]-1H-isoindole-1-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	434.41

View Full Technical Details for NAV 26

Technical Data
Citations

Biological Activity for NAV 26

NAV 26 is a selective Na_v1.7 channel blocker (IC₅₀ = 370 nM). Exhibits >85-fold selectivity for Na_v1.7 over Na_v1.5 and hERG channels. Reduces nociceptive behavior in rat models of pain.

Compound Libraries for NAV 26

NAV 26 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NAV 26

M. Wt	434.41
Formula	C₂₂H₂₁F₃N₂O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1198160-14-3
PubChem ID	44540282
InChi Key	ICGMZCVSHDKQTE-UHFFFAOYSA-N
Smiles	O=C2C1=CC=CC=C1C(C(NCC4=CC=C(OC(F)(F)F)C=C4)=O)N2C3CCOCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for NAV 26

References are publications that support the biological activity of the product.

Macsari 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. J.Med.Chem. 2012 PMID: 22770500