Naltriben mesylate

Name: Naltriben mesylate
Brand: tocris
SKU: 0892

Catalog # 0892

Citations (1)

Datasheet / COA / SDS

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Key Product Details

Description:	Standard δ₂ selective antagonist
Chemical Name:	17-(Cyclopropylmethyl)-6,7-didehydro-3,14β-dihydroxy-4,5α-epoxy-6,7-2',3'-benzo[b]furanomorphinan mesylate
Purity:	≥98% (HPLC)

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Biological Activity

Selective and potent δ-opioid receptor antagonist (K_i values are 0.013, 19 and 152 nM for δ, μ and κ receptors respectively). Displays selectivity for the δ₂ subtype in vivo.

Licensing Information

Sold with the permission of the University of Minnesota

Technical Data

M. Wt	511.59
Formula	C₂₆H₂₅NO₄.CH₃SO₃H
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	122517-78-6
PubChem ID	45073482
InChi Key	XRRFZOCDAWPIBB-IDRHMUJXSA-N
Smiles	C[S](O)(=O)=O.[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC3CC3)[C@]([H])(C4)[C@]1(O)CC1=C2OC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.58	50 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 511.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.91 mL	19.55 mL	39.09 mL
2.5 mM	0.78 mL	3.91 mL	7.82 mL
5 mM	0.39 mL	1.95 mL	3.91 mL
25 mM	0.08 mL	0.39 mL	0.78 mL

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References

References are publications that support the biological activity of the product.

Miyamoto Involvement of delta₂ opioid receptors in the development of mor. dependence in mice. J.Pharmacol.Exp.Ther. 1993 PMID: 8383738
Portoghese Role of spacer and address components in peptidomimetic δ opioid receptor antagonists related to naltrindole. J.Med.Chem. 1991 PMID: 1851846
Thorat and Hammond Modulation of nociception by microinjection of delta-1 and delta-2 opioid receptor ligands in the ventromedial medulla of the rat. J.Pharmacol.Exp.Ther. 1997 PMID: 9399992

Showing 1-1 of 1 citation

Citations (1)

Citations are publications that use Bio-techne products. Selected citations for Naltriben mesylate include:

Gomes et al. (2000) Heterodimerization of μ and δ opioid receptors: A role in opiate synergy. Exp Neurobiol. 20:RC110
PMID: 11069979

Naltriben mesylate

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Biological Activity

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Dilution Calculator

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References

Citations (1)

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