N¹,N¹²-Diethylspermine tetrahydrochloride

Name: N 1 , N 12 -Diethylspermine tetrahydrochloride
Brand: tocris
SKU: 0500

Catalog # 0500

Datasheet / COA / SDS

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Key Product Details

Description:	Polyamine synthase inhibitor
Molecular Weight:	404.29

View Full Technical Details for N¹,N¹²-Diethylspermine tetrahydrochloride

Biological Activity

N¹,N¹²-Diethylspermine tetrahydrochloride is a powerful antineoplastic agent in cultured cells and animal tumors (IC₅₀ = 0.2 μM in L1210 cells). Inhibitor of polyamine synthases. Suppressor of mitochondrial DNA synthesis.

Technical Data

M. Wt	404.29
Formula	C₁₄H₃₄N₄.4HCl
Storage	Store at RT
CAS Number	113812-15-0
PubChem ID	11750054
InChi Key	SCYOBNRPMHJGLB-UHFFFAOYSA-N
Smiles	CCNCCCNCCCCNCCCNCC.Cl.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions

The following data is based on the product molecular weight 404.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.47 mL	12.37 mL	24.73 mL
5 mM	0.49 mL	2.47 mL	4.95 mL
10 mM	0.25 mL	1.24 mL	2.47 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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References

References are publications that support the biological activity of the product.

Bergeron Synthetic polyamine analogues as antineoplastics. J.Med.Chem. 1988 PMID: 3373487
Bergeron Synthesis and bioloigcal evaluation of aminopolyamines. J.Med.Chem. 2005 PMID: 15857111
Porter Combined regulation of arginine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N¹,N¹²-bis(ethyl)spermine. Biochem.J. 1990 PMID: 2344358
Vertino Selective cellular depletion of mitochondrial DNA by the polyamine analog N¹,N¹²-bis(ethyl)spermine and its relationship to polyamine structure and function. Mol.Pharmacol. 1991 PMID: 2017149

Citations

Currently there are no citations for N¹,N¹²-Diethylspermine tetrahydrochloride.

N¹,N¹²-Diethylspermine tetrahydrochloride

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Key Product Details

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Biological Activity

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations

Product Documents

COA

Certificate of Analysis

SDS

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N1,N12-Diethylspermine tetrahydrochloride

Order Information

Shipping Information

Key Product Details

Complete Your Research

Biological Activity

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations

Product Documents

COA

Certificate of Analysis

SDS

Bio-Techne Brands

N¹,N¹²-Diethylspermine tetrahydrochloride