N1,N12-Diethylspermine tetrahydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0500
Polyamine synthase inhibitor
Discontinued Product
0500 has been discontinued.
View all Synthase/Synthetase Inhibitors products.
Key Product Details
Description
Polyamine synthase inhibitor
Product Description
N1,N12-Diethylspermine tetrahydrochloride is a powerful antineoplastic agent in cultured cells and animal tumors (IC50 = 0.2 μM in L1210 cells). Inhibitor of polyamine synthases. Suppressor of mitochondrial DNA synthesis.Product Specifications
Molecular Weight
404.29
Formula
C14H34N4.4HCl
Storage
Store at RT
CAS Number
113812-15-0
PubChem ID
11750054
InChI Key
SCYOBNRPMHJGLB-UHFFFAOYSA-N
SMILES
CCNCCCNCCCCNCCCNCC.Cl.Cl.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 404.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.47 mL | 12.37 mL | 24.73 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.95 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.47 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Vertino Selective cellular depletion of mitochondrial DNA by the polyamine analog N1,N12-bis(ethyl)spermine and its relationship to polyamine structure and function. Mol.Pharmacol. 1991 PMID: 2017149
- Bergeron Synthesis and bioloigcal evaluation of aminopolyamines. J.Med.Chem. 2005 PMID: 15857111
- Porter Combined regulation of arginine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1,N12-bis(ethyl)spermine. Biochem.J. 1990 PMID: 2344358
- Bergeron Synthetic polyamine analogues as antineoplastics. J.Med.Chem. 1988 PMID: 3373487
Product Specific Notices
For research use only
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