N^α-Methylhistamine dihydrochloride

Name: N α -Methylhistamine dihydrochloride
Brand: tocris
SKU: 0573

Catalog # 0573

Datasheet / COA / SDS

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Key Product Details

Description:	Non-selective H₃ agonist
Chemical Name:	N-Methyl-1H-imidazole-4-ethanamine dihydrochloride
Molecular Weight:	198.09

View Full Technical Details for N^α-Methylhistamine dihydrochloride

Biological Activity

N^α-Methylhistamine dihydrochloride is a potent histamine agonist, particularly at H₃ receptors (potency relative to histamine is 81, 185, and 270% at H₁, H₂ and H₃ respectively). Also displays agonist properties at H₄ receptors to which it binds with moderate affinity (K_i = 23 nM).

Technical Data

M. Wt	198.09
Formula	C₆H₁₁N₃.2HCl
Storage	Desiccate at RT
CAS Number	16503-22-3
PubChem ID	16078977
InChi Key	AYUQICXJAMPXPF-UHFFFAOYSA-N
Smiles	Cl.Cl.CNCCC1=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	19.81	100

Preparing Stock Solutions

The following data is based on the product molecular weight 198.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.05 mL	25.24 mL	50.48 mL
5 mM	1.01 mL	5.05 mL	10.10 mL
10 mM	0.50 mL	2.52 mL	5.05 mL
50 mM	0.10 mL	0.50 mL	1.01 mL

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References

References are publications that support the biological activity of the product.

Hill Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 1990 PMID: 2164693
Schwartz A third histamine receptor subtype - characterization, localization and functions of the H₃-receptor. Agents Actions 1990 PMID: 1695431
Zweig Characterization of digitonin-solubilized bovine brain H₃ histamine receptor coupled to a guanine nucleotide-binding protein. J.Neurochem. 1992 PMID: 1328529

N^α-Methylhistamine dihydrochloride

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Key Product Details

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Biological Activity

Technical Data

Solubility

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Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations

Product Datasheets

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Certificate of Analysis

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Nα-Methylhistamine dihydrochloride

Order Information

Shipping Information

Key Product Details

Complete Your Experiment

Biological Activity

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations

Product Datasheets

COA

Certificate of Analysis

SDS

Bio-Techne Brands

N^α-Methylhistamine dihydrochloride