N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu

Name: N -Acetyl- O -phosphono-Tyr-Glu-Glu-Ile-Glu
Brand: Tocris Bioscience
SKU: 1927

Tocris Bioscience, part of Bio-Techne | Catalog # 1927

COA / SDS

Phosphopeptide ligand for src SH2 domain

Discontinued Product

1927 has been discontinued. View all Src Family Kinase Ligands products.

Key Product Details

Description:	Phosphopeptide ligand for src SH2 domain
Chemical Name:	N-Acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl]-L-α-glutamyl-L-isoleucyl]-L-glutamic acid
Molecular Weight:	803.71

View Full Technical Details for N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu

Technical Data
Citations

Biological Activity

N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu is a phosphopeptide ligand for the src SH2 domain (IC₅₀ = 1 μM). Blocks src interactions with EGFR and FAK.

Technical Data

M. Wt	803.71
Formula	C₃₂H₄₆N₅O₁₇P
Single Letter Sequence	YEEIE (Modifications: Tyr-1 = pTyr with C-terminal Ac)
Storage	Desiccate at -20°C
CAS Number	159439-02-8
PubChem ID	42628614
InChi Key	QQEKQSBIEKQXQS-PSCZMIBCSA-N
Smiles	CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References

References are publications that support the biological activity of the product.

Pacofsky Potent dipeptide inhibitors of the pp60^c-src SH2 domain. J.Med.Chem. 1998 PMID: 9599239
Park Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains. Bioorg.Med.Chem.Lett. 2002 PMID: 12217360
Gilmer Peptide inhibitors of src SH3-SH2-phosphoprotein interactions. J.Biol.Chem. 1994 PMID: 7527393

N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu

Tocris Bioscience, part of Bio-Techne | Catalog # 1927

Key Product Details

Biological Activity

Technical Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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