N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu

Name: N -Acetyl- O -phosphono-Tyr-Glu-Glu-Ile-Glu
Brand: Tocris Bioscience
SKU: 1927

Tocris Bioscience a Bio-Techne Brand

Catalog # 1927

COA / SDS

Discontinued Product

1927 has been discontinued. View all Src Family Kinase Ligands products.

Key Product Details

Description:	Phosphopeptide ligand for src SH2 domain
Chemical Name:	N-Acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl]-L-α-glutamyl-L-isoleucyl]-L-glutamic acid
Molecular Weight:	803.71

View Full Technical Details for N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu

Biological Activity

N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu is a phosphopeptide ligand for the src SH2 domain (IC₅₀ = 1 μM). Blocks src interactions with EGFR and FAK.

Technical Data

M. Wt	803.71
Formula	C₃₂H₄₆N₅O₁₇P
Single Letter Sequence	YEEIE (Modifications: Tyr-1 = pTyr with C-terminal Ac)
Storage	Desiccate at -20°C
CAS Number	159439-02-8
PubChem ID	42628614
InChi Key	QQEKQSBIEKQXQS-PSCZMIBCSA-N
Smiles	CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Park Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains. Bioorg.Med.Chem.Lett. 2002 PMID: 12217360
Pacofsky Potent dipeptide inhibitors of the pp60^c-src SH2 domain. J.Med.Chem. 1998 PMID: 9599239
Gilmer Peptide inhibitors of src SH3-SH2-phosphoprotein interactions. J.Biol.Chem. 1994 PMID: 7527393

Citations for N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu

Please visit our Instrument Citation Database to search our collection of scientific articles that feature our instruments.

N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu

Tocris Bioscience a Bio-Techne Brand

Key Product Details

Customers also Viewed

Biological Activity

Technical Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations for N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu

Product Documents

COA

Certificate of Analysis

SDS

Bio-Techne Brands

Stay Connected