MY-5445

Name: MY-5445
Brand: tocris
SKU: 0432
Rating: 4 (1 reviews)

Catalog # 0432

(1)

Datasheet / COA / SDS

Discontinued Product

0432 has been discontinued. View all Phosphodiesterase Inhibitors products.

Order Information

Bio-Techne Corporation

tel: (612) 379-2956

tel: (800) 343-7475 (free phone)

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

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Key Product Details

Description:	PDE5 inhibitor
Chemical Name:	1-(3-Chlorophenylamino)-4-phenylphthalazine

View Full Technical Details for MY-5445

Technical Data
Citations / Reviews (1)

Biological Activity

Specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5 (IC₅₀ = 0.5 μM).

Technical Data

M. Wt	331.8
Formula	C₂₀H₁₄ClN₃
Storage	Store at RT
CAS Number	78351-75-4
PubChem ID	1348
InChi Key	CEHQLKSLMFIHBF-UHFFFAOYSA-N
Smiles	ClC1=CC(NC2=C3C=CC=CC3=C(N=N2)C2=CC=CC=C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mM
Solubility
	DMSO	50
	ethanol	5

Preparing Stock Solutions

The following data is based on the product molecular weight 331.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.03 mL	30.14 mL	60.28 mL
2.5 mM	1.21 mL	6.03 mL	12.06 mL
5 mM	0.60 mL	3.01 mL	6.03 mL
25 mM	0.12 mL	0.60 mL	1.21 mL

Molarity Calculator

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Hagiwara Effect of 1-(3-chloroanilino)-4-phenylphthalazine (MY-5445), a specific inhibitor of cyclic GMP phosphodiesterase, on human platelet aggregation. J.Pharmacol.Exp.Ther. 1984 PMID: 6141286
Hidaka and Endo Selective inhibitors of three forms of cyclic nucleotide phosphodiesterase, basic and potential clinical applications. Adv.Cyclic Nucleotide Protein Phosphorylation Res. 1984 PMID: 6144253

Citations

Currently there are no citations for MY-5445.

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Great product

Name: Abhijit Nirwane | 8th Jan 2018

Species: Other

Assay Type: In Vivo

In vivo reproductive studies