MSC 2032964A

Tocris Bioscience, part of Bio-Techne | Catalog # 5641

Potent and selective ASK1 inhibitor; orally bioavailable
Discontinued Product
5641 has been discontinued. View all ASK1 Inhibitors products.

Key Product Details

Description

Potent and selective ASK1 inhibitor; orally bioavailable

View all ASK1 Inhibitors »

Product Description

MSC 2032964A is a potent and selective ASK1 inhibitor (IC50 = 93 nM). Selective for ASK1 over a panel of 210 kinases. Blocks LPS-induced ASK1 and p38 phosphorylation in cultured mouse astrocytes. Suppresses neuroinflammation in a mouse EAE model. Orally bioavailable and brain penetrant.

Product Specifications

Molecular Weight

362.31

Formula

C16H13F3N6O

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide

CAS Number

1124381-43-6

PubChem ID

25214468

InChI Key

XUKGFHHTSUKORV-UHFFFAOYSA-N

SMILES

O=C(C1=CC=CN=C1)NC2=NN3C(C=C(C(F)(F)F)C=C3NC4CC4)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.25 20
Ethanol 3.62 10 with gentle warming

Preparing Stock Solutions for MSC 2032964A

The following data is based on the product molecular weight 362.31

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.80 mL 69.00 mL 138.00 mL
1 mM 2.76 mL 13.80 mL 27.60 mL
2 mM 1.38 mL 6.90 mL 13.80 mL
10 mM 0.28 mL 1.38 mL 2.76 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for MSC 2032964A

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MSC 2032964A

For research use only

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