MP A08
Tocris Bioscience, part of Bio-Techne | Catalog # 5803
Selective ATP competitive SphK1 and 2 inhibitor; cell permeable
Discontinued Product
5803 has been discontinued.
View all Sphingosine Kinase Inhibitors products.
Key Product Details
Description
Selective ATP competitive SphK1 and 2 inhibitor; cell permeable
Alternative Names
NSC 122314
Product Description
MP A08 is a selective ATP competitive sphingosine kinase 2 and 1 (SphK2/1) inhibitor (Ki values are 6.9 and 27 μM, respectively). Exhibits selectivity for SphK 1 and 2 over other kinases. Inhibits cellular S1P production and increases sphingosine and ceramide levels in vitro. Also induces mitochondrial-associated apoptosis. Reduces tumor growth in a human lung adenocarcinoma xenograft mouse model, by inducing apoptosis and suppressing angiogenesis. Cell permeable.Product Specifications
Molecular Weight
519.64
Formula
C27H25N3O4S2
Storage
Store at -20°C
Chemical Name
4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide
CAS Number
219832-49-2
PubChem ID
420266
InChI Key
FLDBNMYJUMAXDQ-UHFFFAOYSA-N
SMILES
O=S(NC1=CC=CC=C1/N=C/C2=CC=CC=C2NS(C3=CC=C(C)C=C3)(=O)=O)(C4=CC=C(C)C=C4)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.96 | 100 |
Preparing Stock Solutions
for MP A08
The following data is based on the product molecular weight 519.64
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.92 mL | 9.62 mL | 19.24 mL |
| 5 mM | 0.38 mL | 1.92 mL | 3.85 mL |
| 10 mM | 0.19 mL | 0.96 mL | 1.92 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pitman A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget 2015 PMID: 25788259
Product Specific Notices for MP A08
For research use only
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