MP A08

Name: MP A08
Brand: Tocris Bioscience
SKU: 5803

Tocris Bioscience a Bio-Techne Brand

Catalog # 5803

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Key Product Details

Description:	Selective ATP competitive SphK1 and 2 inhibitor; cell permeable
Alternative Names:	NSC 122314
Chemical Name:	4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide
Molecular Weight:	519.64

View Full Technical Details for MP A08

Biological Activity for MP A08

MP A08 is a selective ATP competitive sphingosine kinase 2 and 1 (SphK2/1) inhibitor (K_i values are 6.9 and 27 μM, respectively). Exhibits selectivity for SphK 1 and 2 over other kinases. Inhibits cellular S1P production and increases sphingosine and ceramide levels in vitro. Also induces mitochondrial-associated apoptosis. Reduces tumor growth in a human lung adenocarcinoma xenograft mouse model, by inducing apoptosis and suppressing angiogenesis. Cell permeable.

Technical Data for MP A08

M. Wt	519.64
Formula	C₂₇H₂₅N₃O₄S₂
Storage	Store at -20°C
CAS Number	219832-49-2
PubChem ID	420266
InChi Key	FLDBNMYJUMAXDQ-UHFFFAOYSA-N
Smiles	O=S(NC1=CC=CC=C1/N=C/C2=CC=CC=C2NS(C3=CC=C(C)C=C3)(=O)=O)(C4=CC=C(C)C=C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MP A08

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	51.96	100

Preparing Stock Solutions for MP A08

The following data is based on the product molecular weight 519.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.92 mL	9.62 mL	19.24 mL
5 mM	0.38 mL	1.92 mL	3.85 mL
10 mM	0.19 mL	0.96 mL	1.92 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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References for MP A08

References are publications that support the biological activity of the product.

Pitman A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget 2015 PMID: 25788259

Citations for MP A08

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