ML 67-33

Tocris Bioscience, part of Bio-Techne | Catalog # 6886

K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator
Discontinued Product
6886 has been discontinued. View all Two-P Potassium Channels Activators products.

Key Product Details

Description

K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator

View all Two-P Potassium Channels Activators »

Product Description

ML 67-33 is a K2P potassium channel activator (EC50 values are 21.8 - 29.4 μM, 30.2 μM and 27.3 μM for K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) respectively, expressed in xenopus oocytes). Increases channel currents by activating core gating apparatus of channels. In a mouse migraine model, ML 67-33 improves pain symptoms via activation of TREK 1/2 currents in trigeminal ganglion sensory neurons.

Product Specifications

Molecular Weight

374.27

Formula

C18H17Cl2N5

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2,7-Dichloro-9,10-dihydro-9,9-dimethyl-10-[2-(2H-tetrazol-5-yl)ethyl]acridine

CAS Number

1443290-89-8

PubChem ID

86272454

InChI Key

GQPMJOXQJUGJPG-UHFFFAOYSA-N

SMILES

CC1(C2=CC(Cl)=CC=C2N(C3=CC=C(C=C13)Cl)CCC4=NN=NN4)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.43 100

Preparing Stock Solutions for ML 67-33

The following data is based on the product molecular weight 374.27

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.36 mL 26.72 mL
5 mM 0.53 mL 2.67 mL 5.34 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for ML 67-33

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ML 67-33

For research use only

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