ML 349

Name: ML 349
Brand: Tocris Bioscience
SKU: 5344

Tocris Bioscience, part of Bio-Techne | Catalog # 5344

Citations (6)

COA / SDS

Selective and reversible lysophospholipase 2 (LYPLA2) inhibitor

Discontinued Product

5344 has been discontinued. View all Hydrolase Inhibitors products.

Key Product Details

Description:	Selective and reversible lysophospholipase 2 (LYPLA2) inhibitor
Chemical Name:	(5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone
Purity:	≥98% (HPLC)
Molecular Weight:	454.56

View Full Technical Details for ML 349

Technical Data
Citations

Biological Activity for ML 349

ML 349 is a selective and reversible lysophospholipase 2 (LYPLA2) inhibitor (IC₅₀ = 144 nM). Displays selectively over LYPLA1 and 20 other serine hydrolases (IC₅₀ values are >3000 and >10,000 nM respectively).

Compound Libraries for ML 349

ML 349 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 349

M. Wt	454.56
Formula	C₂₃H₂₂N₂O₄S₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	890819-86-0
PubChem ID	16193817
InChi Key	YVIJPELUPZUEJX-UHFFFAOYSA-N
Smiles	COC1=CC=C(N2CCN(C(C3=CC4=C(C(C=CC=C5)=C5S(C4)(=O)=O)S3)=O)CC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for ML 349

References are publications that support the biological activity of the product.

Hernandez APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells. Cell Che.Bio. 2017 PMID: 28065656
Adibekian Characterization of a selective, reversible inhibitor of lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program 2010 PMID: 24624468