ML 3403
Tocris Bioscience, part of Bio-Techne | Catalog # 4586
p38 inhibitor
Discontinued Product
4586 has been discontinued.
View all p38 Inhibitors products.
Product Description
ML 3403 is a p38 MAPK inhibitor (IC50 = 0.38 μM). Inhibits the release of IL-1β and TNF-α in a peripheral blood mononuclear cell (PBMC) assay (IC50 values are 0.039 and 0.16 μM respectively).Product Specifications
Molecular Weight
404.50
Formula
C23H21FN4S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
[5-[4-(4-Fluorophenyl)-2-methylthio-1H-imidazol-4-yl]-N-(1-phenylethyl)-2-pyridinamine
CAS Number
549505-65-9
PubChem ID
6419739
InChI Key
VXPWQNBKEIVYIS-UHFFFAOYSA-N
SMILES
FC(C=C3)=CC=C3C(N=C(SC)N2)=C2C1=CC=NC(NC(C)C4=CC=CC=C4)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.45 | 100 | |
| Ethanol | 20.23 | 50 |
Preparing Stock Solutions
for ML 3403
The following data is based on the product molecular weight 404.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.47 mL | 12.36 mL | 24.72 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.94 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.47 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kammerer Pharmacokinetics of ML3403 ({4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-pyridinylimidazole-type p38 mitogen-activated protein kinase inhibitor. Drug Metab.Dispos. 2007 PMID: 17344341
- Laufer Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J.Med.Chem. 2003 PMID: 12852754
Product Specific Notices for ML 3403
For research use only
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