MK 212 hydrochloride

Name: MK 212 hydrochloride
Brand: Tocris Bioscience
SKU: 0941

Catalog # 0941

Citations (6)

COA / SDS

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Key Product Details

Description:	5-HT_2C agonist
Chemical Name:	6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	235.12

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Biological Activity

MK 212 hydrochloride is a 5-HT receptor agonist; displays selectivity for 5-HT_2C over 5-HT_2A (IC₅₀ values are 0.028 and 0.42 μM for human 5-HT_2C and 5-HT_2A receptors expressed in HEK293 cells respectively).

Technical Data

M. Wt	235.12
Formula	C₈H₁₁ClN₄.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	61655-58-1
PubChem ID	198421
InChi Key	PFIZGLUIYAZQFU-UHFFFAOYSA-N
Smiles	ClC1=CN=CC(N2CCNCC2)=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	11.76	50 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 235.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.51 mL	42.53 mL	85.06 mL
2.5 mM	1.70 mL	8.51 mL	17.01 mL
5 mM	0.85 mL	4.25 mL	8.51 mL
25 mM	0.17 mL	0.85 mL	1.70 mL

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References

References are publications that support the biological activity of the product.

Jensen Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 2013 PMID: 23301527
Hemrick-Luecke and Fuller Involvement of 5-HT_2A receptors in the elevation of rat serum corticosterone concentration by quipazine and MK-212. Eur.J.Pharmacol. 1996 PMID: 8891601
Conn and Sanders-Bush Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT₂ and 5-HT_1C) receptors. J.Pharmacol.Exp.Ther. 1987 PMID: 3039120

Citations for MK 212 hydrochloride (6)

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Citations are publications that use Bio-Techne products. Selected citations for MK 212 hydrochloride include:

Bigford et al. (2012) 5-Hydroxytryptamine 5HT2C receptors form a protein complex with N-MthD.-aspartate GluN2A subunits and activate phosphorylation of Src protein to modulate motoneuronal depolarization. J Biol Chem. 287:11049
PMID: 22291020
Murray et al. (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol. 106:925
PMID: 21653728
Murray et al. (2010) Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med. 16:694
PMID: 20512126
Yu and Yamaguchi (2010) Endogenous serotonin acts on 5-HT2C-like receptors in key vocal areas of the brain stem to initiate vocalizations in Xenopus laevis. J Biomed Sci. 103:648
PMID: 19955293
Yu and Yamaguchi (2009) 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations. J Neurophysiol. 102:752
PMID: 19474172
Kawahara et al. (2008) Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass. J Neurosci. 28:12834
PMID: 19036977

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