Mitochondrial fusion promoter M1

Product Description

Mitochondrial fusion promoter M1 is a mitochondrial fusion promoter. Protects cells from mitochondrial fragmentation-associated cell death. Induces mitochondrial fusion in effector T cells imposing a memory T cell morphology. Improves cellular respiration and potentiates glucose-stimulated insulin-secretion in cholesterol-exposed pancreatic β cells. Mitochondrial fusion promoter M1 also enhances mitochondrial dynamics and transport velocity in axons of the sciatic nerve in vitro and enhances axon regeneration in the optic nerve in an in vivo model of nerve damage.

Solubility

Preparing Stock Solutions for Mitochondrial fusion promoter M1

The following data is based on the product molecular weight 364.05

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.75 mL	13.73 mL	27.47 mL
5 mM	0.55 mL	2.75 mL	5.49 mL
10 mM	0.27 mL	1.37 mL	2.75 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Au A small molecule M1 promotes optic nerve regeneration to restore target-specific neural activity and visual function. Proc.Natl.Acad.Sci.USA 2022 PMID: 36306327
• Wang A small molecule promotes mitochondrial fusion in mammalian cells. Angew.Chem.Int.Ed.Engl. 2012 PMID: 22907892
• Buck Mitochondrial dynamics controls T cell fate through metabolic programming. Cell 2016 PMID: 27293185
• Asalla Restoring mitochondrial function: a small molecule-mediated approach to enhance glucose stimulated insulin secretion in cholesterol accumulated pancreatic beta cells. Sci.Rep. 2016 PMID: 27282931