Miconazole nitrate

Name: Miconazole nitrate
Brand: Tocris Bioscience
SKU: 3016

Tocris Bioscience a Bio-Techne Brand

Catalog # 3016

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Key Product Details

Description:	Azole antifungal agent
Chemical Name:	1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole nitrate
Purity:	≥99% (HPLC)
Molecular Weight:	479.14

View Full Technical Details for Miconazole nitrate

Biological Activity for Miconazole nitrate

Miconazole nitrate is a antifungal agent. Inhibits lanosterol demethylase and induces formation of reactive oxygen species. Enhances the generation of mature oligodendrocytes from progenitor cells in vitro and promotes myelination in vivo. Attenuates disease severity in a mouse model of multiple sclerosis. Brain penetrant.

Compound Libraries for Miconazole nitrate

Miconazole nitrate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Miconazole nitrate

M. Wt	479.14
Formula	C₁₈H₁₄Cl₄N₂O.HNO₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	22832-87-7
PubChem ID	68553
InChi Key	MCCACAIVAXEFAL-UHFFFAOYSA-N
Smiles	ClC1=CC(Cl)=CC=C1COC(CN3C=CN=C3)C2=CC=C(Cl)C=C2Cl.O[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Miconazole nitrate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	47.91	100
	ethanol	4.79	10

Preparing Stock Solutions for Miconazole nitrate

The following data is based on the product molecular weight 479.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.09 mL	10.44 mL	20.87 mL
5 mM	0.42 mL	2.09 mL	4.17 mL
10 mM	0.21 mL	1.04 mL	2.09 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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Reconstitution Calculator

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References for Miconazole nitrate

References are publications that support the biological activity of the product.

Hubler Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature 2018 PMID: 30046109
Najim Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo. Nature 2015 PMID: 25896324
Chang Effect of miconazole on intracellular Ca²⁺ levels and proliferation in human osteosarcoma cells. Life Sci. 2005 PMID: 15826876

Citations for Miconazole nitrate

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