Miconazole nitrate
Tocris Bioscience, part of Bio-Techne | Catalog # 3016
Azole antifungal agent
Discontinued Product
3016 has been discontinued.
View all Miscellaneous Compounds products.
Product Description
Miconazole nitrate is a antifungal agent. Inhibits lanosterol demethylase and induces formation of reactive oxygen species. Enhances the generation of mature oligodendrocytes from progenitor cells in vitro and promotes myelination in vivo. Attenuates disease severity in a mouse model of multiple sclerosis. Brain penetrant.Product Specifications
Molecular Weight
479.14
Formula
C18H14Cl4N2O.HNO3
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole nitrate
CAS Number
22832-87-7
PubChem ID
68553
InChI Key
MCCACAIVAXEFAL-UHFFFAOYSA-N
SMILES
ClC1=CC(Cl)=CC=C1COC(CN3C=CN=C3)C2=CC=C(Cl)C=C2Cl.O[N+]([O-])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.91 | 100 | |
| Ethanol | 4.79 | 10 |
Preparing Stock Solutions
for Miconazole nitrate
The following data is based on the product molecular weight 479.14
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.09 mL | 10.44 mL | 20.87 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.17 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.09 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Najim Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo. Nature 2015 PMID: 25896324
- Hubler Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature 2018 PMID: 30046109
- Chang Effect of miconazole on intracellular Ca2+ levels and proliferation in human osteosarcoma cells. Life Sci. 2005 PMID: 15826876
Product Specific Notices for Miconazole nitrate
For research use only
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