Melphalan

Name: Melphalan
Brand: Tocris Bioscience
SKU: 4619

Tocris Bioscience, part of Bio-Techne | Catalog # 4619

Citations (2)

COA / SDS

DNA alkylating agent; cytotoxic and antineoplastic

Discontinued Product

4619 has been discontinued. View all Additional Apoptosis-related Compounds products.

Key Product Details

Description:	DNA alkylating agent; cytotoxic and antineoplastic
Chemical Name:	4-[Bis(2-Chloroethyl)amino]-L-phenylalanine
Purity:	≥95% (HPLC)
Molecular Weight:	305.2

View Full Technical Details for Melphalan

Technical Data
Citations

Biological Activity for Melphalan

Melphalan is a DNA alkylating agent; induces cytotoxicity through the formation of stable interstrand and intrastrand crosslinks within DNA. Inhibits growth of PC-3 cells (IC₅₀ values are 0.074 and 0.77 μg/ml for sequential dosing and single dosing respectively).

Technical Data for Melphalan

M. Wt	305.2
Formula	C₁₃H₁₈Cl₂N₂O₂
Storage	Store at RT
Purity	≥95% (HPLC)
CAS Number	148-82-3
PubChem ID	460612
InChi Key	SGDBTWWWUNNDEQ-LBPRGKRZSA-N
Smiles	ClCCN(CCCl)C1=CC=C(C[C@H](N)C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Melphalan

References are publications that support the biological activity of the product.

Bauer and Povirk Specificity and kinetics of interstrand and intrastrand bifunctional alkylation by nitrogen mustards at a G-G-C sequence. Nucleic Acids Res. 1997 PMID: 9092631
Mougenot In vitro cytotoxic effect of melp. and pilot phase II study in hormone-refractory prostate cancer. Anticancer Res. 2006 PMID: 16821586
Blumberg An alkylating agent for multiple myeloma: melp. JAMA. 1965 PMID: 14239026

Product Documents for Melphalan

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Melphalan, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov