Melperone hydrochloride

Name: Melperone hydrochloride
Brand: tocris
SKU: 2495

Catalog # 2495

Citations (1)

Datasheet / COA / SDS

Discontinued Product

2495 has been discontinued. View all 5-HT2A Receptor Antagonists products.

Order Information

Bio-Techne Corporation

tel: (800) 343-7475 (free phone)

tel: (612) 379-2956

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

View Distributors

Key Product Details

Description:	5-HT_2A antagonist; also D₂ antagonist; neuroleptic
Chemical Name:	1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	299.81

View Full Technical Details for Melperone hydrochloride

Complete Your Research

Biological Activity

Melperone hydrochloride is an atypical neuroleptic; 5-HT_2A/D₂ receptor antagonist (K_i values are 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC. Also binds adrenergic α₁ and α₂ receptors (K_i values are 180 and 150 nM respectively).

Technical Data

M. Wt	299.81
Formula	C₁₆H₂₂FNO.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1622-79-3
PubChem ID	15386
InChi Key	MQHYXXIJLKFQGY-UHFFFAOYSA-N
Smiles	Cl.CC1CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	29.98	100
	DMSO	29.98	100

Preparing Stock Solutions

The following data is based on the product molecular weight 299.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.34 mL	16.68 mL	33.35 mL
5 mM	0.67 mL	3.34 mL	6.67 mL
10 mM	0.33 mL	1.67 mL	3.34 mL
50 mM	0.07 mL	0.33 mL	0.67 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Seeman Atypical neuroleptics have low affinity for DA D₂ receptors or are selective for D₄ receptors. Neuropsychopharmacology. 1997 PMID: 9015795
Ichikawa Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase DA and acetylcholine release in rat medial prefrontal cortex: role of 5-HT_1A receptor agonism. Brain Res. 2002 PMID: 12445705
Uhr P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6. J.Psychopharmacol.

Citations (1)

Showing 1 - 1 of 1 citation Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for Melperone hydrochloride include:

Hacker et al. (2015) Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of MetF. with Experimental Substrates. Brain Res. 10:e0136451
PMID: 26327616

There are no citations that match your criteria.

Showing 1 - 1 of 1 citation Showing All

Product Documents

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

Melperone hydrochloride

Order Information

Shipping Information

Key Product Details

Complete Your Research

Complete Your Experiment

Biological Activity

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (1)

Product Documents

COA

Certificate of Analysis

SDS

Bio-Techne Brands

Stay Connected