Melperone hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2495

5-HT2A antagonist; also D2 antagonist; neuroleptic
Discontinued Product
2495 has been discontinued. View all 5-HT2A Receptor Antagonists products.

Key Product Details

Description

5-HT2A antagonist; also D2 antagonist; neuroleptic

View all 5-HT2A Receptor Antagonists »

Product Description

Melperone hydrochloride is an atypical neuroleptic; 5-HT2A/D2 receptor antagonist (Ki values are 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC. Also binds adrenergic α1 and α2 receptors (Ki values are 180 and 150 nM respectively).

Product Specifications

Molecular Weight

299.81

Formula

C16H22FNO.HCl

Storage

Desiccate at RT

Purity

≥99% (HPLC)

Chemical Name

1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone hydrochloride

CAS Number

1622-79-3

PubChem ID

15386

InChI Key

MQHYXXIJLKFQGY-UHFFFAOYSA-N

SMILES

Cl.CC1CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 29.98 100
DMSO 29.98 100

Preparing Stock Solutions for Melperone hydrochloride

The following data is based on the product molecular weight 299.81

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.34 mL 16.68 mL 33.35 mL
5 mM 0.67 mL 3.34 mL 6.67 mL
10 mM 0.33 mL 1.67 mL 3.34 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Melperone hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Melperone hydrochloride

For research use only

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