Melanocyte-stimulating hormone release inhibiting factor

Name: Melanocyte-stimulating hormone release inhibiting factor
Brand: Tocris Bioscience
SKU: 1929

Tocris Bioscience a Bio-Techne Brand

Catalog # 1929

COA / SDS

Discontinued Product

1929 has been discontinued. View all Additional Melanocortin Receptor Peptides products.

Key Product Details

Description:	Inhibitor of α-MSH release; inhibits opioid effects in vivo
Alternative Names:	Pro-Leu-Gly amide, MIF-I, PLG
Molecular Weight:	284.36

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Biological Activity for Melanocyte-stimulating hormone release inhibiting factor

Melanocyte-stimulating hormone release inhibiting factor is a inhibitor of melanocyte-stimulating hormone (MSH) release. Blocks the release of α-MSH, increases brain dopamine levels and antagonizes physiological and behavioral opioid effects in vivo.

Technical Data for Melanocyte-stimulating hormone release inhibiting factor

M. Wt	284.36
Formula	C₁₃H₂₄N₄O₃
Single Letter Sequence	PLG (Modifications: Gly-3 = C-terminal amide)
Storage	Desiccate at -20°C
CAS Number	2002-44-0
PubChem ID	92910
InChi Key	NOOJLZTTWSNHOX-UWVGGRQHSA-N
Smiles	[H]N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Melanocyte-stimulating hormone release inhibiting factor

References are publications that support the biological activity of the product.

Kavaliers and Hirst Inhibitory influences of FMRFamide and PLG on stress-induced opioid analgesia and activity. Brain Res. 1986 PMID: 2871903
Mishra Pharmacology of L-Prolyl-L-Leucyl-Glycinamide (PLG): a review. Methods Find.Exp.Clin.Pharmacol. 1983 PMID: 6136640
Pugsley and Lippmann Synthetic melanocyte stimulating hormone release inhibiting factor (MIF). Part III: effect of L-prolyl-N-MthD.-leucyl-glycinamide and MIF on biogenic amine turnover. Arzneimittelforschung 1977 PMID: 23796
Plotnikoff and Kastin Pharmacological studies with a tripeptide, Prolyl-Leucyl Glycine amide. Arch.Int.Pharmacodyn.Ther. 1974 PMID: 4156639

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Melanocyte-stimulating hormone release inhibiting factor

Tocris Bioscience a Bio-Techne Brand

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References for Melanocyte-stimulating hormone release inhibiting factor

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